Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | CTSV | O60911 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7718548 | 0.81 | CYP2D6 (0.50) | PKMLMNAKDM4ESMN1; SMN2HTT | |
| SCHEMBL5966224 | 0.79 | PKM (0.79) | PKMCTSVCTSLLMNALCK | |
| SCHEMBL7830300 | 0.77 | PKM (0.75) | PKMCTSVCTSLLMNALCK | |
| SCHEMBL27906227 | 0.75 | POLB (0.49) | PKMLMNALCKFYNKDM4E | |
| SCHEMBL890810 | 0.73 | PKM (1.00) | PKMCTSVCTSLLMNALCK | |
| SCHEMBL6437918 | 0.72 | KDM4E (0.52) | PKMLMNAKDM4ESMN1; SMN2HTT | |
| SCHEMBL16689291 | 0.72 | PKM (0.76) | PKMCTSVCTSLLMNALCK | |
| SCHEMBL3842143 | 0.72 | PKM (0.55) | PKMCTSVCTSLLMNASMN1; SMN2 | |
| SCHEMBL1675659 | 0.72 | PKM (0.55) | PKMLMNALCKFYNKDM4E | |
| SCHEMBL2681693 | 0.71 | PKM (0.78) | PKMCTSVCTSLLMNALCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002087587-A2 | 4-AMINOSULFONYLQUINAZOLINES AND -QUINOLINES AS TYROSINE KINASE INHIBITORS | CELLTECH R & D LIMITED (GB) | 2002-11-07 | — | — | WO | disclosed |