Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.37 |
| ▸ | FABP4 | P15090 | 3/20 | 0.37 |
| ▸ | FABP3 | P05413 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.35 |
| ▸ | P2RY12 | Q9H244 | 3/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 2/20 | 0.34 |
| ▸ | TOP1 | P11387 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2323700 | 0.88 | LTB4R (0.46) | PPARGPPARALTB4RPDE3BPDE3A | |
| SCHEMBL2326928 | 0.86 | LTB4R (0.45) | PPARGPPARALTB4RFABP4PDE3B | |
| SCHEMBL2324225 | 0.86 | LTB4R (0.48) | PPARGPPARALTB4RFABP4SIRT2 | |
| SCHEMBL2323189 | 0.80 | LTB4R (0.43) | PPARGPPARALTB4RPDE3BPDE3A | |
| SCHEMBL2327922 | 0.80 | LTB4R (0.46) | PPARGPPARALTB4RPDE3BPDE3A | |
| SCHEMBL2330018 | 0.80 | PDE3B (0.48) | PPARGPPARALTB4RPDE3BPDE3A | |
| SCHEMBL5420223 | 0.79 | LTB4R (0.45) | PPARGPPARALTB4RPDE3BPDE3A | |
| SCHEMBL2323012 | 0.79 | LTB4R (0.44) | PPARGPPARALTB4RPDE3BPDE3A | |
| SCHEMBL2326187 | 0.78 | LTB4R (0.46) | PPARGPPARALTB4RFABP4PDE3B | |
| SCHEMBL2330597 | 0.78 | LTB4R (0.46) | PPARGPPARALTB4RFABP4PDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246808-A1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-10-09 | — | — | EP | claimed |
| WO-2001051473-A1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-07-19 | — | — | WO | claimed |
| EP-1246808-A1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001051473-A1 | 1,2-DIARYL BENZIMIDAZOLES FOR TREATING ILLNESSES ASSOCIATED WITH A MICROGLIA ACTIVATION | SCHERING AKTIENGESELLSCHAFT (DE) | 2001-07-19 | — | — | WO | disclosed |