⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11357849 | 0.81 | — | — | |
| SCHEMBL2700611 | 0.76 | — | — | |
| SCHEMBL19353622 | 0.70 | — | — | |
| SCHEMBL1098236 | 0.70 | — | — | |
| 1,2-Dichloroethane SCHEMBL28862235 | 0.67 | — | — | |
| SCHEMBL258515 | 0.67 | — | — | |
| SCHEMBL1599328 | 0.65 | — | — | |
| SCHEMBL28867938 | 0.65 | ALDH1A1 (0.32) | — | |
| SCHEMBL11575077 | 0.64 | — | — | |
| SCHEMBL1107630 | 0.64 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-3358811-B2 | — | — | 2002-12-24 | — | — | JP | claimed |
| EP-0635021-B1 | PROCESS FOR PRODUCING DERIVATIVES OF BIS(AMINOMETHYL) PHOSPHINIC ACID | HOECHST AG (DE) | 1996-10-09 | — | — | EP | claimed |
| US-5510504-A | Process for the preparation of derivatives of bis(amino-methyl) phosphinic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-04-23 | — | — | US | claimed |
| EP-0635021-A1 | PROCESS FOR PRODUCING DERIVATIVES OF BIS(AMINOMETHYL) PHOSPHINIC ACID. | HOECHST AG (DE) | 1995-01-25 | — | — | EP | claimed |
| WO-1993020086-A1 | PROCESS FOR PRODUCING DERIVATIVES OF BIS(AMINOMETHYL) PHOSPHINIC ACID | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-10-14 | — | — | WO | claimed |
| CN-115124573-A | Novel cytotoxic molecules for use in cell binding molecule-drug conjugates | 杭州多禧生物科技有限公司 | 2022-09-30 | — | — | CN | disclosed |
| CN-107074879-B | Novel cytotoxic molecules for use in cell binding molecule-drug conjugates | 杭州多禧生物科技有限公司 | 2022-04-15 | — | — | CN | disclosed |
| EP-3041846-B1 | NOVEL CYTOTOXIC AGENTS FOR CONJUGATION OF DRUGS TO CELL BINDING MOLECULE | HANGZHOU DAC BIOTECH CO LTD (CN) | 2018-11-07 | — | — | EP | disclosed |
| US-9988408-B2 | Cytotoxic agents for conjugation to a cell binding molecule | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2018-06-05 | — | — | US | disclosed |
| US-9988408-B2 | Cytotoxic agents for conjugation to a cell binding molecule | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2018-06-05 | — | — | US | disclosed |
| US-20160207949-A1 | NOVEL CYTOTOXIC AGENTS FOR CONJUGATION TO A CELL BINDING MOLECULE | HANGZHOU DAC BIOTECH CO., LTD (CN) | 2016-07-21 | — | — | US | disclosed |
| US-20160207949-A1 | NOVEL CYTOTOXIC AGENTS FOR CONJUGATION TO A CELL BINDING MOLECULE | HANGZHOU DAC BIOTECH CO., LTD (CN) | 2016-07-21 | — | — | US | disclosed |
| US-5510504-A | Process for the preparation of derivatives of bis(amino-methyl) phosphinic acid | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-04-23 | — | — | US | disclosed |
| EP-0635021-A1 | PROCESS FOR PRODUCING DERIVATIVES OF BIS(AMINOMETHYL) PHOSPHINIC ACID. | HOECHST AG (DE) | 1995-01-25 | — | — | EP | disclosed |
| WO-1993020086-A1 | PROCESS FOR PRODUCING DERIVATIVES OF BIS(AMINOMETHYL) PHOSPHINIC ACID | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-10-14 | — | — | WO | disclosed |
| EP-0435059-A1 | Retroviral protease inhibitors | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-07-03 | — | — | EP | disclosed |
| EP-0173163-B1 | METAL ORGANO PHOSPHOROUS COMPOUNDS FOR NMR ANALYSIS | Research Corporation (US) | 1988-12-07 | — | — | EP | disclosed |
| US-4749560-A | Metal organo phosphorous compounds for NMR analysis | RESEARCH CORPORATION (US) | 1988-06-07 | — | — | US | disclosed |
| EP-0173163-A1 | Metal organo phosphorous compounds for NMR analysis | Research Corporation (US) | 1986-03-05 | — | — | EP | disclosed |
| US-4130411-A | DI(HALOMETHYL)ARYL PHOSPHINE OXIDES | M&T CHEMICALS INC. (US) | 1978-12-19 | — | — | US | disclosed |