SCHEMBL77200

SCHEMBL77200

Nc1cc(Cl)[c]cc1Cl

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27577447 0.81
SCHEMBL3118468 0.79
SCHEMBL28585364 0.79
SCHEMBL27578699 0.75
SCHEMBL28476056 0.75
SCHEMBL14994350 0.75
SCHEMBL104357 0.75
SCHEMBL27746634 0.72 AHR (0.32)
SCHEMBL28338476 0.70 GAA (0.50)
SCHEMBL2515959 0.70 NPC1 (0.45)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 860 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3201208-B1 BORONIC ACID DERIVATIVES MERCK PATENT GMBH (DE) 2021-03-24 EP claimed
EP-3201207-B1 BORONIC ACID DERIVATIVES MERCK PATENT GMBH (DE) 2021-02-24 EP claimed
EP-3201205-B1 BORONIC ACID DERIVATIVES MERCK PATENT GMBH (DE) 2020-05-13 EP claimed
US-10640520-B2 Boronic acid derivatives MERCK PATENT GMBH (DE) 2020-05-05 US claimed
US-10294246-B2 Substituted boronic acids and boronate esters as immunoproteasome inhibitors MERCK PATENT GMBH (DE) 2019-05-21 US claimed
US-20180179231-A1 BORONIC ACID DERIVATIVES MERCK PATENT GMBH (DE) 2018-06-28 US claimed
US-20180105539-A1 BORONIC ACID DERIVATIVES MERCK PATENT GMBH (DE) 2018-04-19 US claimed
US-20180105538-A1 BORONIC ACID DERIVATIVES MERCK PATENT GMBH (DE) 2018-04-19 US claimed
EP-3201205-A1 BORONIC ACID DERIVATIVES Merck Patent GmbH (DE) 2017-08-09 EP claimed
EP-3201207-A1 BORONIC ACID DERIVATIVES Merck Patent GmbH (DE) 2017-08-09 EP claimed
WO-2016050355-A1 BORONIC ACID DERIVATIVES MERCK PATENT GMBH (DE) 2016-04-07 WO claimed
WO-2016050356-A1 BORONIC ACID DERIVATIVES MERCK PATENT GMBH (DE) 2016-04-07 WO claimed
WO-2016050359-A1 BORONIC ACID DERIVATIVES MERCK PATENT GMBH (DE) 2016-04-07 WO claimed
US-7390925-B2 Oxime-containing acyl guanidines as beta-secretase inhibitors BRISTOL-MYERS SQUIBB COMPANY (US) 2008-06-24 US claimed
JP-2008518889-A 2008-06-05 JP claimed
US-7291642-B2 Bradykinin-B1 antagonists, process for their preparation and their use as medicaments BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-11-06 US claimed
US-20070232581-A1 Oxime-Containing Acyl Guanidines as Beta-Secretase Inhibitors BRISTOL-MYERS SQUIBB COMPANY 2007-10-04 US claimed
EP-1812405-A1 NOVEL BRADYKININ B1 ANTAGONISTS, METHOD FOR PRODUCING THE SAME AND THE USE THEREOF AS DRUGS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2007-08-01 EP claimed
US-20060100219-A1 Novel bradykinin-B1 antagonists, process for their preparation and their use as medicaments BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-05-11 US claimed
WO-2006048209-A1 NOVEL BRADYKININ B1 ANTAGONISTS, METHOD FOR PRODUCING THE SAME AND THE USE THEREOF AS DRUGS BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2006-05-11 WO claimed