Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKD3 | O94806 | 3/20 | 0.54 |
| ▸ | PRKCG | P05129 | 3/20 | 0.54 |
| ▸ | PRKCB | P05771 | 3/20 | 0.54 |
| ▸ | PRKCA | P17252 | 3/20 | 0.54 |
| ▸ | PRKCH | P24723 | 3/20 | 0.54 |
| ▸ | PRKCI | P41743 | 3/20 | 0.54 |
| ▸ | PRKCE | Q02156 | 3/20 | 0.54 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.54 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.54 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.54 |
| ▸ | PRKD1 | Q15139 | 3/20 | 0.54 |
| ▸ | LPAR1 | Q92633 | 5/20 | 0.51 |
| ▸ | LPAR3 | Q9UBY5 | 5/20 | 0.51 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.51 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.47 |
| ▸ | TLR2 | O60603 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1773674 | 1.00 | PRKD3 (0.54) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Hydrochloric Acid SCHEMBL9808836 | 1.00 | PRKD3 (0.54) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Hydrochloric Acid SCHEMBL7718400 | 1.00 | PRKD3 (0.54) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Hydrochloric Acid SCHEMBL1772881 | 1.00 | PRKD3 (0.54) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Hydrochloric Acid SCHEMBL1773357 | 1.00 | PRKD3 (0.54) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Hydrochloric Acid SCHEMBL9808821 | 1.00 | PRKD3 (0.54) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Hydrochloric Acid SCHEMBL7720123 | 1.00 | PRKD3 (0.54) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL2184995 | 0.98 | PRKD3 (0.56) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| Hydrochloric Acid SCHEMBL252989 | 0.98 | PRKD3 (0.51) | PRKD3PRKCGPRKCBPRKCAPRKCH | |
| SCHEMBL8674072 | 0.98 | PRKD3 (0.56) | PRKD3PRKCGPRKCBPRKCAPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6387395-B1 | N-[1, (1-1) -dialkyloxy] - and N- [1, (1-1) -dialkenyloxy]- alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor | EPPSTEIN DEBORAH A (US) | 2002-05-14 | — | — | US | disclosed |
| US-5622712-A | CONSISTS OF A DRUG AND A QUATERNARY AMMONIUM SALT COMPOUND AS A LIPID COMPONENT | SYNTEX (U.S.A.) INC. (US) | 1997-04-22 | — | — | US | disclosed |
| US-5550289-A | FOR DNA TRANSFECTION | SYNTEX (U.S.A.) INC. (US) | 1996-08-27 | — | — | US | disclosed |
| US-5545412-A | USING LIPOPHILIC COMPOUNDS TO TRANSFECT DNA AND FOR DRUG DELIVERY BY FORMING COMPLEXES TO PENETRATE CELLULAR MEMBRANES | SYNTEX (U.S.A.) INC. (US) | 1996-08-13 | — | — | US | disclosed |
| US-5366737-A | Drug delivery, DNA transfection | SYNTEX (U.S.A.) INC. (US) | 1994-11-22 | — | — | US | disclosed |
| US-5208036-A | Complexing a liposomal composition with a quaternary ammonium diether | SYNTEX (U.S.A.) INC. (US) | 1993-05-04 | — | — | US | disclosed |
| US-5049386-A | Drug and DNA delivery | SYNTEX (U.S.A.) INC. (US) | 1991-09-17 | — | — | US | disclosed |
| US-4946787-A | DOUBLE COATED LIPOSOME COMPLEX MADE UP OF POLYANION AND A LIPID | SYNTEX (U.S.A.) INC. (US) | 1990-08-07 | — | — | US | disclosed |
| EP-0187702-B1 | N-(OMEGA,OMEGA-1-DIALKOXY)- AND N-(OMEGA,OMEGA-1-DIALKENOXY)-ALK-1-YL-N,N,N-TRISUBSTITUTED AMMONIUM SURFACTANTS, THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | SYNTEX (U.S.A.) INC. (US) | 1990-03-14 | — | — | EP | disclosed |
| US-4897355-A | LIPISOME-POLYANION COMPLEX | SYNTEX (U.S.A.) INC. (US) | 1990-01-30 | — | — | US | disclosed |
| EP-0188311-A2 | Pharmaceutical formulation of nicardipine and 1,2-dioxy-omega-trialkylammonium compounds | SYNTEX (U.S.A.) INC. (US) | 1986-07-23 | — | — | EP | disclosed |
| EP-0187702-A1 | N-(omega,omega-1-dialkoxy)- and N-(omega,omega-1-dialkenoxy)-alk-1-yl-N,N,N-trisubstituted ammonium surfactants, their preparation and pharmaceutical formulations containing them | SYNTEX (U.S.A.) INC. (US) | 1986-07-16 | — | — | EP | disclosed |