SCHEMBL7720191

SCHEMBL7720191

COc1ccc(COCC([O])=O)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 2/20 0.53
NPC1 O15118 2/20 0.51
RAB9A P51151 2/20 0.51
POLB P06746 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
IDO1 P14902 2/20 0.50
AGXT P21549 2/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
PLA2G4B P0C869 1/20 0.49
FFAR1 O14842 1/20 0.49
LDHA P00338 1/20 0.49
ALDH1A1 P00352 2/20 0.47
MAPT P10636 1/20 0.47
F2RL1 P55085 1/20 0.47
HDAC4 P56524 1/20 0.47
HDAC6 Q9UBN7 1/20 0.47
CALM1 P0DP23 1/20 0.46
NFKB1 P19838 1/20 0.45
NFKB2 Q00653 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL99313 0.85 FFAR1 (0.57) HTTNPC1RAB9APOLBSMN1; SMN2
SCHEMBL19002576 0.85 HTT (0.53) HTTNPC1RAB9APOLBSMN1; SMN2
SCHEMBL4706402 0.84 HTT (0.56) HTTNPC1RAB9APOLBSMN1; SMN2
SCHEMBL7364455 0.84 IDO1 (0.53) HTTNPC1RAB9APOLBSMN1; SMN2
SCHEMBL10072105 0.82 HTT (0.50) HTTNPC1RAB9APOLBSMN1; SMN2
SCHEMBL22340181 0.81 IDO1 (0.50) HTTNPC1RAB9APOLBSMN1; SMN2
SCHEMBL21169193 0.81 HTT (0.49) HTTNPC1RAB9APOLBSMN1; SMN2
SCHEMBL22759520 0.81 HTT (0.57) HTTNPC1RAB9APOLBSMN1; SMN2
SCHEMBL14935708 0.81 CA1 (0.50) HTTNPC1RAB9APOLBSMN1; SMN2
SCHEMBL11543183 0.81 HTT (0.50) HTTNPC1RAB9APOLBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6391916-B1 ANTITUMOR AGENTS THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2002-05-21 US claimed
US-6391916-B1 ANTITUMOR AGENTS THE HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) 2002-05-21 US disclosed