Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 9/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 9/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11077830 | 0.99 | SLC6A4 (0.98) | SLC6A4SLC6A3SLC6A2HTR1A | |
| SCHEMBL10638396 | 0.94 | SLC6A4 (0.88) | SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL10635558 | 0.93 | SLC6A4 (0.86) | SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL11068578 | 0.92 | SLC6A4 (0.85) | SLC6A4SLC6A3SLC6A2 | |
| Hydrochloric Acid SCHEMBL10638308 | 0.89 | SLC6A4 (0.98) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL11640206 | 0.88 | SLC6A4 (0.78) | SLC6A4SLC6A3SLC6A2 | |
| Hydrochloric Acid SCHEMBL10638536 | 0.85 | SLC6A4 (0.74) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL11110171 | 0.85 | SLC6A4 (0.74) | SLC6A4SLC6A3SLC6A2 | |
| Mobenzoxamine SCHEMBL2111666 | 0.83 | SLC6A4 (0.70) | SLC6A4SLC6A3SLC6A2 | |
| SCHEMBL17549656 | 0.82 | SLC6A4 (0.70) | SLC6A4SLC6A3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6387389-B1 | Sustained-release derivatives of hydroxylated analogs of substituted 1-[2[bis(aryl)methoxy]ethyl]-piperazines and -homopiperazines and their use | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | 2002-05-14 | — | — | US | disclosed |
| EP-0937053-A1 | SUSTAINED-RELEASE DERIVATIVES OF HYDROXYLATED ANALOGS OF SUBSTITUTED 1- 2 BIS(ARYL)METHOXY]ETHYL]-PIPERAZINES AND -HOMOPIPERAZINES AND THEIR USE AS NONCOMPETITIVE ANTAGONISTS OF DOPAMINE REUPTAKE | THE UNITED STATES OF AMERICA, as represented by the Secretary of the Department of Health and Human Services (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998018769-A1 | SUSTAINED-RELEASE DERIVATIVES OF HYDROXYLATED ANALOGS OF SUBSTITUTED 1-[2[BIS(ARYL)METHOXY]ETHYL]-PIPERAZINES AND -HOMOPIPERAZINES AND THEIR USE AS NONCOMPETITIVE ANTAGONISTS OF DOPAMINE REUPTAKE | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1998-05-07 | — | — | WO | disclosed |
| EP-0099148-B1 | PIPERAZINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL PREPARATIONS CONTAINING THEM | GIST-BROCADES N.V. (NL) | 1988-02-17 | — | — | EP | disclosed |
| US-4476129-A | DOPAMINERGIC AND ANTICMOLINERGIC AGENTS | GIST-BROCADES N.V. (NL) | 1984-10-09 | — | — | US | disclosed |