SCHEMBL7721760

SCHEMBL7721760

CCc1cc2c(cc1Oc1ccc(C(=O)O)cc1)C(C)(C)CCC2(C)C

nearest known ligand 0.71

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
RXRA P19793 18/20 0.71
RXRB P28702 5/20 0.64
RXRG P48443 5/20 0.64
HNF4A P41235 2/20 0.60
RARB P10826 3/20 0.56
RARG P13631 3/20 0.56
RARA P10276 2/20 0.56
CYP26A1 O43174 1/20 0.54
CYP3A4 P08684 1/20 0.54
CYP26B1 Q9NR63 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8016720 0.87 CYP3A4 (0.56) RXRARXRBRXRGHNF4ARARB
SCHEMBL7716696 0.85 RXRA (0.62) RXRARXRBRXRGHNF4ARARB
SCHEMBL6910205 0.83 RXRA (1.00) RXRARXRBRXRGRARBRARG
SCHEMBL6822271 0.82 RXRA (0.73) RXRARXRBRXRGHNF4ARARB
SCHEMBL7720651 0.80 RXRA (0.70) RXRARXRBRXRGHNF4ARARB
SCHEMBL7720657 0.79 RXRA (1.00) RXRARXRBRXRGRARBRARG
SCHEMBL1072441 0.78 RXRA (1.00) RXRARXRBRXRGHNF4ARARB
SCHEMBL6240778 0.77 RXRA (0.72) RXRARXRBRXRGHNF4ACYP26A1
SCHEMBL6244434 0.76 RXRA (0.70) RXRARXRBRXRGHNF4ARARB
SCHEMBL1073916 0.76 RXRA (1.00) RXRARXRBRXRGHNF4ARARB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6391287-B1 STORAGE STABLE COMPOSITIONS L'OREAL (FR) 2002-05-21 US claimed
EP-1019049-A1 METHODS AND COMPOSITIONS FOR TREATING AND/OR PREVENTING NON-INSULIN DEPENDENT DIABETES MELLITUS (NIDDM) USING SPECIFIC RETINOID COMPOUNDS Galderma Research & Development, S.N.C. (FR) 2000-07-19 EP claimed
WO-1998042340-A9 RETINOID RELATED MOLECULES FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS 1999-03-04 WO claimed
WO-1998042340-A1 RETINOID RELATED MOLECULES FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 1998-10-01 WO claimed
US-5766610-A USEFUL FOR TREATMENT OF MAMMALIAN SKIN AND HAIR, RHEUMATISM, RESIPIRATORY SYSTEM DISORDER, CARDIOVASCULAR AND VISION DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-06-16 US claimed
EP-0679630-B1 Bicyclic aromatic compounds, pharmaceutical and cosmetic compositions containing them and uses CIRD GALDERMA (FR) 1998-05-06 EP claimed
US-6391287-B1 STORAGE STABLE COMPOSITIONS L'OREAL (FR) 2002-05-21 US disclosed
US-6162815-A RXR-agonist polycyclic aromatic compounds, pharmaceutical/cosmetic compositions comprising said compound and uses thereof CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2000-12-19 US disclosed
US-6156788-A Polycyclic aromatic compounds and pharmaceutical/cosmetic compositions comprised thereof CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2000-12-05 US disclosed
EP-1019049-A1 METHODS AND COMPOSITIONS FOR TREATING AND/OR PREVENTING NON-INSULIN DEPENDENT DIABETES MELLITUS (NIDDM) USING SPECIFIC RETINOID COMPOUNDS Galderma Research & Development, S.N.C. (FR) 2000-07-19 EP disclosed
US-6015569-A PYRIDINE OR PYRROLE DERIVATIVES OF POLYCYCLIC AROMATICS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 2000-01-18 US disclosed
WO-1998042340-A9 RETINOID RELATED MOLECULES FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS 1999-03-04 WO disclosed
WO-1998042340-A1 RETINOID RELATED MOLECULES FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS GALDERMA RESEARCH & DEVELOPMENT, S.N.C. (FR) 1998-10-01 WO disclosed
US-5766610-A USEFUL FOR TREATMENT OF MAMMALIAN SKIN AND HAIR, RHEUMATISM, RESIPIRATORY SYSTEM DISORDER, CARDIOVASCULAR AND VISION DISORDERS CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) 1998-06-16 US disclosed