Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Asimadoline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 known ✓ | P41145 | 3/20 | 1.00 |
| ▸ | OPRM1 | P35372 | 1/20 | 1.00 |
| ▸ | OPRD1 | P41143 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Asimadoline SCHEMBL2473545 | 1.00 | OPRK1 (1.00) | OPRK1OPRM1OPRD1CYP2D6 | |
| Asimadoline SCHEMBL155020 | 1.00 | OPRK1 (1.00) | OPRK1OPRM1OPRD1CYP2D6 | |
| Asimadoline SCHEMBL8717354 | 1.00 | OPRK1 (1.00) | OPRK1OPRM1OPRD1CYP2D6 | |
| Asimadoline SCHEMBL6923822 | 1.00 | OPRK1 (1.00) | OPRK1OPRM1OPRD1CYP2D6 | |
| Asimadoline SCHEMBL13639176 | 1.00 | OPRK1 (1.00) | OPRK1OPRM1OPRD1CYP2D6 | |
| Asimadoline SCHEMBL26923202 | 0.99 | OPRK1 (0.98) | OPRK1OPRM1OPRD1CYP2D6 | |
| Asimadoline SCHEMBL1179586 | 0.99 | OPRK1 (0.98) | OPRK1OPRM1OPRD1CYP2D6 | |
| Asimadoline SCHEMBL8011656 | 0.99 | OPRK1 (0.98) | OPRK1OPRM1OPRD1CYP2D6 | |
| SCHEMBL8720266 | 0.94 | OPRK1 (0.89) | OPRK1OPRM1OPRD1CYP2D6 | |
| SCHEMBL9015325 | 0.94 | OPRK1 (0.89) | OPRK1OPRM1OPRD1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6344566-B1 | AMIDATION AND REDUCTION AND CONVERSION WITH ACID; ASIMADOLINE | MERCK PATENT GMBH (DE) | 2002-02-05 | — | — | US | claimed |