Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7726553 | 0.92 | PARP1 (0.38) | SCN9AHDAC4HDAC1HDAC8HDAC3 | |
| SCHEMBL7721963 | 0.90 | SIGMAR1 (0.39) | SCN9AHDAC4HDAC1HDAC8HDAC3 | |
| SCHEMBL7722280 | 0.90 | SCN9A (0.43) | SCN9AHDAC4HDAC1HDAC8HDAC3 | |
| SCHEMBL7729578 | 0.88 | HDAC4 (0.42) | SCN9AHDAC4HDAC1HDAC8HDAC3 | |
| SCHEMBL7726142 | 0.88 | HDAC4 (0.42) | SCN9AHDAC4HDAC1HDAC8HDAC3 | |
| Hydrochloric Acid SCHEMBL7722278 | 0.87 | SCN9A (0.35) | SCN9AHDAC4HDAC1HDAC8HDAC3 | |
| SCHEMBL7729111 | 0.85 | HDAC4 (0.39) | SCN9AHDAC4HDAC1HDAC8HDAC3 | |
| SCHEMBL7729494 | 0.84 | SCN9A (0.40) | SCN9AHDAC4HDAC1HDAC8HDAC3 | |
| SCHEMBL7729729 | 0.83 | SCN9A (0.39) | SCN9AHDAC4HDAC1HDAC8HDAC3 | |
| SCHEMBL7722336 | 0.83 | SCN9A (0.36) | SCN9AHDAC4HDAC1HDAC8HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |
| WO-2000001714-A1 | EFFLUX PUMP INHIBITORS | MICROCIDE PHARMACEUTICALS, INC. (US) | 2000-01-13 | — | — | WO | disclosed |