Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLCG1 | P19174 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7728186 | 0.90 | PLCG1 (0.38) | PLCG1ELANEALDH1A1MAPTHPGD | |
| SCHEMBL7722624 | 0.89 | L3MBTL1 (0.39) | PLCG1ELANEALDH1A1MAPTHPGD | |
| SCHEMBL7729156 | 0.88 | PLCG1 (0.38) | PLCG1ELANEALDH1A1MAPTHPGD | |
| SCHEMBL7729351 | 0.88 | PLCG1 (0.38) | PLCG1ELANEALDH1A1MAPTHPGD | |
| SCHEMBL7722513 | 0.88 | PLCG1 (0.36) | PLCG1ELANEPOLBSMN1; SMN2HTR2A | |
| SCHEMBL7728913 | 0.88 | PLCG1 (0.36) | PLCG1ELANEALDH1A1MAPTHPGD | |
| SCHEMBL7729305 | 0.84 | PLCG1 (0.35) | PLCG1ELANEALDH1A1MAPTHPGD | |
| SCHEMBL7722523 | 0.83 | L3MBTL1 (0.39) | PLCG1ELANEALDH1A1MAPTHPGD | |
| SCHEMBL7734427 | 0.82 | L3MBTL1 (0.38) | PLCG1ELANEALDH1A1MAPTHPGD | |
| SCHEMBL7729819 | 0.81 | L3MBTL1 (0.37) | PLCG1ELANEALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458780-B1 | IMIDAZO(5,1-B)THIAZOLE GROUP AT THE 2-POSITION ON THE CARBAPENEM RING HAVE HIGH ANTI-MICROBIAL ACTIVITIES AGAINST .BETA.-LACTAMASE PRODUCING BACTERIA, MRSA, RESISTANT-PSEUDOMONAS AERUGINOSA, PRSP, ENTEROCOCCI, AND | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-10-01 | — | — | US | disclosed |