Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 19/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | GLA | P06280 | 1/20 | 0.61 |
| ▸ | CASP1 | P29466 | 1/20 | 0.61 |
| ▸ | CASP7 | P55210 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | PDE2A | O00408 | 1/20 | 0.61 |
| ▸ | PDE6D | O43924 | 1/20 | 0.61 |
| ▸ | USP2 | O75604 | 1/20 | 0.61 |
| ▸ | PDE9A | O76083 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | PDE6A | P16499 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1962446 | 0.81 | PDE5A (1.00) | PDE5AKDM4EALDH1A1KMT2AGLA | |
| SCHEMBL7722411 | 0.81 | PDE5A (0.77) | PDE5AKDM4EALDH1A1KMT2AGLA | |
| SCHEMBL1962489 | 0.81 | PDE5A (0.68) | PDE5AKDM4EALDH1A1KMT2AGLA | |
| Zaprinast SCHEMBL50328 | 0.80 | PDE5A (0.65) | PDE5AKDM4EALDH1A1KMT2AGLA | |
| SCHEMBL7721486 | 0.80 | PDE5A (0.64) | PDE5AKDM4EALDH1A1KMT2AGLA | |
| SCHEMBL7965712 | 0.80 | PDE5A (1.00) | PDE5AKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL7377997 | 0.80 | PDE5A (0.73) | PDE5AKDM4EALDH1A1KMT2AGLA | |
| SCHEMBL3701453 | 0.80 | PDE5A (0.69) | PDE5AKDM4EALDH1A1KMT2AGLA | |
| Zaprinast SCHEMBL6374345 | 0.80 | PDE5A (0.70) | PDE5AKDM4EALDH1A1KMT2AGLA | |
| SCHEMBL6198487 | 0.79 | PDE5A (0.65) | PDE5AKDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347146-B1 | FUSED PYRIMIDINE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-09-01 | — | — | EP | claimed |
| EP-0347146-A2 | Fused pyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-12-20 | — | — | EP | claimed |
| US-6391885-B1 | CONTROLLING APOPTOSIS IN AUTOIMMUNE DISEASE | CELL PATHWAYS, INC. | 2002-05-21 | — | — | US | disclosed |
| US-6060477-A | Method of treating a patient having precancerous lesions with phenyl cycloamino pyrimidinone derivatives | CELL PATHWAYS, INC. (US) | 2000-05-09 | — | — | US | disclosed |
| EP-0347146-B1 | FUSED PYRIMIDINE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1993-09-01 | — | — | EP | disclosed |
| US-5047404-A | Fused pyrimidine derivatives bronchodilator agents, antiallergens | SMITH KLINE & FRENCH LABORATORIES, LTD. (GB) | 1991-09-10 | — | — | US | disclosed |
| EP-0347146-A2 | Fused pyrimidine derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-12-20 | — | — | EP | disclosed |