Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 18/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
| ▸ | CASP1 | P29466 | 1/20 | 0.58 |
| ▸ | CASP7 | P55210 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | PDE2A | O00408 | 1/20 | 0.57 |
| ▸ | PDE6D | O43924 | 1/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | PDE9A | O76083 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | PDE6A | P16499 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7965712 | 0.81 | PDE5A (1.00) | PDE5AKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL7076702 | 0.81 | PDE5A (0.62) | PDE5AKDM4EALDH1A1KMT2AGLA | |
| SCHEMBL7164458 | 0.81 | GUSB (0.81) | PDE5AKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL7722659 | 0.80 | PDE5A (0.67) | PDE5AKDM4EALDH1A1KMT2AGLA | |
| SCHEMBL7377997 | 0.79 | PDE5A (0.73) | PDE5AKDM4EALDH1A1KMT2AGLA | |
| Zaprinast SCHEMBL6374345 | 0.79 | PDE5A (0.70) | PDE5AKDM4EALDH1A1KMT2AGLA | |
| SCHEMBL7408452 | 0.79 | PDE5A (0.67) | PDE5AKDM4EALDH1A1KMT2AGLA | |
| SCHEMBL7722832 | 0.78 | PDE5A (1.00) | PDE5AKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL7414076 | 0.78 | PDE5A (0.69) | PDE5AKDM4EALDH1A1KMT2AGLA | |
| SCHEMBL7722716 | 0.78 | PDE5A (1.00) | PDE5AKDM4EALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9040583-B2 | Treatment of disorders associated with G protein-coupled receptor 35 (GPR35) | TEMPLE UNIVERSITY-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2015-05-26 | — | — | US | disclosed |
| US-20120122987-A1 | TREATMENT OF DISORDERS ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 35 (GPR35) | TEMPLE UNIVERSITY OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2012-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120122987-A1 | TREATMENT OF DISORDERS ASSOCIATED WITH G PROTEIN-COUPLED RECEPTOR 35 (GPR35) | GPR35, GPR68, GRM5 | PDE5A 1508/4885KDM4E 4836/4885ALDH1A1 2520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.