Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Guanosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 4/20 | 0.75 |
| ▸ | ADORA2A known ✓ | P29274 | 2/20 | 0.75 |
| ▸ | ADORA2B known ✓ | P29275 | 1/20 | 0.75 |
| ▸ | ADORA1 known ✓ | P30542 | 1/20 | 0.75 |
| ▸ | DPP4 | P27487 | 1/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.75 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.75 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.75 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.75 |
| ▸ | GAPDH | P04406 | 1/20 | 0.75 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.75 |
| ▸ | STAT6 | P42226 | 1/20 | 0.75 |
| ▸ | PI4KA | P42356 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.75 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.75 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.75 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.75 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.75 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Guanosine SCHEMBL531212 | 1.00 | ADORA3 (0.75) | ADORA3ADORA2ADPP4MEN1SLC28A1 | |
| Guanosine SCHEMBL6856847 | 1.00 | ADORA3 (0.75) | ADORA3ADORA2ADPP4MEN1SLC28A1 | |
| Guanosine SCHEMBL20695784 | 0.96 | ADORA1 (0.70) | ADORA3ADORA2ADPP4MEN1SLC28A1 | |
| Guanosine SCHEMBL15656516 | 0.96 | ADORA1 (0.70) | ADORA3ADORA2ADPP4MEN1SLC28A1 | |
| Guanosine SCHEMBL3926761 | 0.95 | ADORA3 (0.68) | ADORA3ADORA2ADPP4MEN1SLC28A1 | |
| Guanosine SCHEMBL8199614 | 0.95 | ADORA3 (0.68) | ADORA3ADORA2ADPP4MEN1SLC28A1 | |
| Guanosine SCHEMBL27960563 | 0.92 | P2RY2 (0.70) | ADORA3ADORA2ADPP4MEN1SLC28A1 | |
| Guanosine SCHEMBL24049417 | 0.92 | HPGD (0.76) | ADORA3ADORA2AADORA2BHPGDNT5E | |
| Guanosine SCHEMBL24049416 | 0.92 | HPGD (0.76) | ADORA3ADORA2AADORA2BHPGDNT5E | |
| Guanosine SCHEMBL11986902 | 0.92 | HPGD (0.76) | ADORA3ADORA2AADORA2BHPGDNT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002004684-A1 | ROLE OF PPH1 GENE IN PULMONARY HYPERTENSION | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2002-01-17 | — | — | WO | claimed |