Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | MAP2K4 | P45985 | 5/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | BCR | P11274 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.37 |
| ▸ | MAPKAPK3 | Q16644 | 1/20 | 0.37 |
| ▸ | MAPK6 | Q16659 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9778524 | 0.85 | HTR2A (0.44) | HTR2AHTR1AHTR7KDM4EALDH1A1 | |
| SCHEMBL8350202 | 0.84 | MAP2K4 (0.42) | HTR2AMAP2K4HTR1AHTR7KDM4E | |
| SCHEMBL9778496 | 0.83 | HTR2A (0.52) | HTR2AMAP2K4KDM4EALDH1A1HPGD | |
| SCHEMBL1545286 | 0.83 | HTR2A (0.42) | HTR2AMAP2K4HTR1AHTR7KDM4E | |
| SCHEMBL1545504 | 0.83 | ADRA1D (0.44) | HTR2AMAP2K4HTR1AHTR7KDM4E | |
| SCHEMBL27263489 | 0.83 | DRD4 (0.49) | MAP2K4HTR1AHTR7PLK1DRD2 | |
| SCHEMBL1545843 | 0.82 | HTR2A (0.41) | HTR2AMAP2K4HTR1AHTR7KDM4E | |
| Hydrochloric Acid SCHEMBL7726743 | 0.81 | HTR2A (0.41) | HTR2AMAP2K4HTR1AHTR7KDM4E | |
| SCHEMBL1544905 | 0.81 | ADRA1D (0.49) | HTR2AMAP2K4HTR1AHTR7DRD2 | |
| SCHEMBL1545365 | 0.81 | PARP1 (0.54) | HTR2AHTR1AHTR7KDM4EPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420390-B1 | ANALGESIC AGENTS | AVENTIS PHARMACEUTICALS INC. | 2002-07-16 | — | — | US | disclosed |
| US-RE37729-E1 | 4-Heteroaryl-1-piperidinealkylamines and derivatives thereof and their therapeutic utility | AVENTIS PHARMACEUTICALS INC. | 2002-06-04 | — | — | US | disclosed |
| US-6251907-B1 | 1-(aryloxyalkyl)-4-(heteroaryl) piperazines and related compounds useful as antipsychotics and analgesics | AVENTIS PHARMACEUTICALS INC. | 2001-06-26 | — | — | US | disclosed |
| US-6001834-A | PSYCHOLOGICAL DISORDERS, ANALGESICS | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1999-12-14 | — | — | US | disclosed |
| US-5965546-A | ANTIPSYCHOTIC AND ANALGESIC AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-12 | — | — | US | disclosed |
| US-5919798-A | USEFUL AS ANTIPSYCHOTIC AND ANALGESIC AGENTS. | HOECHST MARION ROUSSEL, INC. (US) | 1999-07-06 | — | — | US | disclosed |
| US-5889035-A | 1-(Arylthioalkyl, arylaminoalkyl or arylmethylenealkyl)-3-(heteroaryl) pyrrolidines and related compounds useful as antipsychotics and analgesics | HOECHST MARION ROUSSEL, INC. (US) | 1999-03-30 | — | — | US | disclosed |
| US-5889004-A | PSYCHOLOGICAL DISORDERS, ANALGESICS | HOECHST MARION ROUSSEL, INC. (US) | 1999-03-30 | — | — | US | disclosed |
| US-5874435-A | PSYCHOLOGICAL DISORDERS; ANALGESICS | HOECHST MARION ROUSSEL, INC. (US) | 1999-02-23 | — | — | US | disclosed |
| US-5854263-A | 1- (1,4-benzodioxanyl)alkyl!-3-(heteroaryl) pyrrolidines and related compounds and their therapeutic utility | HOECHST MARION ROUSSEL, INC. (US) | 1998-12-29 | — | — | US | disclosed |
| US-5843977-A | (3-heteroaryl-1-pyrrolidinyl) alkoxy!-3,4-dihydro-1(2H)-naphthalenones and related compounds and their therapeutic utility | HOECHST MARION ROSUEEL, INC. | 1998-12-01 | — | — | US | disclosed |
| US-5843949-A | 1-(1H-indolyloxyalkyl)-4-(heteroaryl)piperazines and related compounds useful as antipsychotics and analgesics | HOECHST MARION ROUSSEL, INC. | 1998-12-01 | — | — | US | disclosed |
| US-5840727-A | ANTIPSYCHOTICS, ANALGESICS | AVENTIS PHARMACEUTICALS INC. | 1998-11-24 | — | — | US | disclosed |
| US-5811430-A | 1 (2-pyrimidinyloxy) alkyl!-4- (heteroaryl) Piperidines and related compounds and their therapeutic utility | HOECHST MARION ROUSSEL, INC. | 1998-09-22 | — | — | US | disclosed |
| US-5811435-A | 2- (4-heteroaryl-1-piperidinyl)alkyl!-1,3-dioxanes and related compounds and their therapeutic utility | HOECHST MARION RUSSEL, INC. | 1998-09-22 | — | — | US | disclosed |
| US-5776963-A | ANTIPSYCHOTIC AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1998-07-07 | — | — | US | disclosed |
| US-5589495-A | ANTIPSYCHOTIC AGENTS, ANALGESICS | HOECHST MARION ROUSSEL, INC. (US) | 1996-12-31 | — | — | US | disclosed |