SCHEMBL7722896

SCHEMBL7722896

CCc1ccc(C(F)(F)Oc2ccc(CCc3ccc(OC(F)(F)F)c(F)c3)cc2)cc1

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
DAO P14920 1/20 0.39
PPARD Q03181 1/20 0.38
PPARA Q07869 1/20 0.38
GPR84 Q9NQS5 1/20 0.38
TSHR P16473 1/20 0.36
CACNA1H O95180 1/20 0.36
SLC6A4 P31645 3/20 0.36
SLC6A3 Q01959 3/20 0.36
PDE2A O00408 1/20 0.35
EPHX2 P34913 2/20 0.35
NR1H4 Q96RI1 1/20 0.35
TRPV1 Q8NER1 1/20 0.35
SLC7A5 Q01650 1/20 0.34
HCRTR1 O43613 4/20 0.34
HCRTR2 O43614 4/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7731909 0.93 DAO (0.36) DAOPPARDPPARAGPR84TSHR
SCHEMBL7722475 0.91 TSHR (0.39) PPARDPPARATSHRCACNA1HSLC6A4
SCHEMBL7735298 0.90 S1PR1 (0.42) DAOPPARDPPARAGPR84CACNA1H
SCHEMBL7730306 0.90 SLC7A5 (0.39) PPARDPPARATSHRCACNA1HPDE2A
SCHEMBL7734833 0.89 S1PR1 (0.39) PPARASLC7A5
SCHEMBL7722866 0.88 SERPINE1 (0.39) PPARDPPARATSHRCACNA1HPDE2A
SCHEMBL7731641 0.87 CACNA1H (0.36) DAOPPARDPPARAGPR84CACNA1H
SCHEMBL7729682 0.87 TSHR (0.45) DAOGPR84TSHRSLC6A4SLC6A3
SCHEMBL7722839 0.86 SLC7A5 (0.37) DAOPPARDPPARAGPR84TSHR
SCHEMBL7734959 0.86 DAO (0.40) DAOPPARDPPARAGPR84TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed