SCHEMBL772296

SCHEMBL772296

NC1c2ncn([C@@H]3O[C@H](CO)C(O)C3O)c2N=CN1N

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADA P00813 4/20 0.63
ALDH1A1 P00352 2/20 0.49
TP53 P04637 2/20 0.49
HTT P42858 2/20 0.49
BLM P54132 2/20 0.49
GMNN O75496 1/20 0.49
LMNA P02545 1/20 0.49
NFKB1 P19838 1/20 0.49
DNMT1 P26358 1/20 0.49
THPO P40225 1/20 0.49
MTOR P42345 1/20 0.49
RAB9A P51151 1/20 0.49
HBB P68871 1/20 0.49
PMP22 Q01453 1/20 0.49
KDM4E B2RXH2 2/20 0.48
SMN1; SMN2 Q16637 2/20 0.48
TDP1 Q9NUW8 1/20 0.48
GAA P10253 1/20 0.48
TSHR P16473 1/20 0.48
MAPT P10636 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL136037 0.89 ADA (0.61) ADAALDH1A1TP53HTTBLM
SCHEMBL2028602 0.89 ADA (0.61) ADAALDH1A1TP53HTTBLM
SCHEMBL5064838 0.88 ADA (0.60) ADAALDH1A1TP53HTTBLM
SCHEMBL4259957 0.88 ADA (0.49) ADAALDH1A1TP53HTTBLM
SCHEMBL288325 0.87 ADA (0.58) ADAALDH1A1TP53HTTBLM
SCHEMBL899393 0.87 ADA (0.58) ADAALDH1A1TP53HTTBLM
SCHEMBL8000695 0.87 ADA (0.58) ADAALDH1A1TP53HTTBLM
SCHEMBL3345754 0.87 ADA (0.60) ADAALDH1A1TP53HTTBLM
SCHEMBL6297520 0.84 ADA (0.55) ADAALDH1A1TP53HTTBLM
SCHEMBL13727118 0.84 ADA (0.55) ADAALDH1A1TP53HTTBLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 114 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240024243-A1 Fine Dry Particulate Adenosine Compositions and Topical Formulations Including the Same LABORATORY SKIN CARE, INC. 2024-01-25 US claimed
EP-1765844-B1 PURINE NUCLEOTIDE DERIVATIVES SOLVELL AS (NO) 2014-07-30 EP claimed
US-8153609-B2 Purine nucleotide derivatives LAURAS AS (NO) 2012-04-10 US claimed
US-20110207689-A1 THE TREATMENT OF HEARING LOSS AUCKLAND UNISERVICES LIMITED 2011-08-25 US claimed
CN-102159209-A The treatment of hearing loss AUCKLAND UNISERVICES LTD 2011-08-17 CN claimed
EP-2328577-A1 THE TREATMENT OF HEARING LOSS Auckland UniServices Limited (NZ) 2011-06-08 EP claimed
WO-2010019057-A1 THE TREATMENT OF HEARING LOSS AUCKLAND UNISERVICES LIMITED (NZ) 2010-02-18 WO claimed
US-20080293665-A1 Purine Nucleotide Derivatives LAURAS AS (NO) 2008-11-27 US claimed
US-20070232560-A1 Treatment of skin with adenosine or adenosine analog UNIVERSITY OF MASSACHUSETTS, A MASSACHUSETTS CORPORATION 2007-10-04 US claimed
EP-1765844-A2 PURINE NUCLEOTIDE DERIVATIVES Lauras AS (NO) 2007-03-28 EP claimed
US-20060240056-A1 Treatment of skin with adenosine or adenosine analog UNIVERSITY OF MASSACHUSETTS, A MASSACHUSETTS CORPORATION 2006-10-26 US claimed
WO-2005123755-A2 PURINE NUCLEOTIDE DERIVATIVES LAURAS AS (NO) 2005-12-29 WO claimed
JP-57206396-A None JP disclosed
US-20240024243-A1 Fine Dry Particulate Adenosine Compositions and Topical Formulations Including the Same LABORATORY SKIN CARE, INC. 2024-01-25 US disclosed
US-20210251901-A1 Fine Dry Particulate Adenosine Compositions and Topical Formulations Including the Same LABORATORY SKIN CARE, INC. 2021-08-19 US disclosed
US-20200121603-A1 Fine Dry Particulate Adenosine Compositions and Topical Formulations Including the Same LABORATORY SKIN CARE, INC. 2020-04-23 US disclosed
WO-1994023723-A1 ADENOSINE RECEPTOR AGONISTS FOR THE PROMOTION OF WOUND HEALING NEW YORK UNIVERSITY (US) 1994-10-27 WO disclosed
US-5248770-A Labels such as fluorescent or radioactive compounds THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1993-09-28 US disclosed
US-4968672-A DRUG DELIVERY; DIURETICS, KIDNEY DISORDERS, HYPOTENSIVE AGENTS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1990-11-06 US disclosed
JP-S57206396-A PREPARATION OF CYCLIC-3',5'-ADENYLIC ACID BY FERMENTATION METHOD KIKKOMAN CORP 1982-12-17 JP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110207689-A1 THE TREATMENT OF HEARING LOSS ADORA1, ADORA2A, ADORA3 ADA 7/4885ALDH1A1 279/4885TP53 2017/4885
US-20080293665-A1 Purine Nucleotide Derivatives CGAS, PDE8A, PDE7A ADA 24/4885ALDH1A1 3225/4885TP53 3284/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.