Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 8/20 | 0.45 |
| ▸ | RAB9A | P51151 | 8/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14694258 | 0.81 | MAPT (0.49) | MAPTNPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL2411656 | 0.79 | MEN1 (0.58) | MAPTNPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL14091695 | 0.79 | NPC1 (0.54) | MAPTNPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL31696760 | 0.78 | MAPT (0.47) | MAPTNPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL1716280 | 0.78 | MAPT (0.50) | MAPTNPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL19203749 | 0.75 | MAPT (0.48) | MAPTNPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL14035666 | 0.75 | MAPT (0.48) | MAPTNPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL14008869 | 0.75 | MAPT (0.45) | MAPTNPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL4677894 | 0.75 | MAPT (0.58) | MAPTNPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL9081963 | 0.75 | KMO (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420367-B1 | RAS GENE | SHIONOGO & CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1097933-A1 | PYRIMIDINE DERIVATIVES EXHIBITING ANTITUMOR ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2001-05-09 | — | — | EP | disclosed |