Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.59 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CES2 | O00748 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11362791 | 0.84 | TSHR (0.61) | TSHRALDH1A1SMN1; SMN2LMNACES2 | |
| SCHEMBL296300 | 0.84 | TSHR (0.61) | TSHRALDH1A1SMN1; SMN2LMNACES2 | |
| SCHEMBL2651119 | 0.84 | TSHR (0.61) | TSHRALDH1A1SMN1; SMN2LMNACES2 | |
| SCHEMBL7733006 | 0.83 | TRPV1 (0.56) | TSHRALDH1A1SMN1; SMN2LMNACES2 | |
| SCHEMBL6275759 | 0.83 | TSHR (0.56) | TSHRALDH1A1SMN1; SMN2LMNACES2 | |
| SCHEMBL9911538 | 0.83 | TSHR (0.56) | TSHRPTPN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL48947 | 0.83 | TSHR (0.59) | TSHRALDH1A1SMN1; SMN2LMNACES2 | |
| SCHEMBL4685756 | 0.83 | TSHR (0.59) | TSHRALDH1A1SMN1; SMN2LMNACES2 | |
| SCHEMBL2082576 | 0.83 | TSHR (0.59) | TSHRALDH1A1SMN1; SMN2LMNACES2 | |
| SCHEMBL1694325 | 0.83 | TSHR (0.59) | TSHRALDH1A1SMN1; SMN2LMNACES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6476266-B1 | Diamino compound and production process for the same | CHISSO CORPORATION (JP) | 2002-11-05 | — | — | US | disclosed |
| US-4348395-A | 1,4-Dihydropyridazine compounds | BAYER AKTIENGESELLSCHAFT (DE) | 1982-09-07 | — | — | US | disclosed |
| EP-0001439-B1 | 1-N-SUBSTITUTED 1.4-DIHYDROPYRIDAZINE DERIVATIVES, METHOD FOR THEIR PREPARATION AND THEIR USE FOR PHARMACEUTICALS | BAYER AG (DE) | 1981-01-28 | — | — | EP | disclosed |
| EP-0001439-A1 | 1-N-substituted 1.4-dihydropyridazine derivatives, method for their preparation and their use for pharmaceuticals | BAYER AG (DE) | 1979-04-18 | — | — | EP | disclosed |