SCHEMBL7724057

SCHEMBL7724057

COc1cc(Nc2ncc(-c3ccccc3C(=O)OCc3ccccc3)o2)ccc1-c1cnco1

nearest known ligand 0.83

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
IMPDH2 P12268 20/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1473187 0.91 IMPDH2 (1.00) IMPDH2
SCHEMBL1473618 0.88 IMPDH2 (0.83) IMPDH2
SCHEMBL1473869 0.88 IMPDH2 (0.68) IMPDH2
SCHEMBL1473990 0.87 IMPDH2 (0.66) IMPDH2
SCHEMBL1475772 0.86 IMPDH2 (0.82) IMPDH2
SCHEMBL1473987 0.86 IMPDH2 (0.80) IMPDH2
SCHEMBL1473475 0.85 IMPDH2 (1.00) IMPDH2
SCHEMBL1475417 0.84 IMPDH2 (1.00) IMPDH2
SCHEMBL1473135 0.82 IMPDH2 (1.00) IMPDH2
SCHEMBL1473908 0.82 IMPDH2 (0.73) IMPDH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6399773-B1 AUTOIMMUNE DISEASE; TRANSPLANTING ORGANS BRISTOL-MYERS SQUIBB CO. 2002-06-04 US disclosed