SCHEMBL7724405

SCHEMBL7724405

COC(=O)[C@@H](Cc1ccccc1)NCc1ccc(NN)nc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 2/20 0.51
L3MBTL1 Q9Y468 1/20 0.49
SIRT2 Q8IXJ6 3/20 0.48
ALDH1A1 P00352 2/20 0.44
THRB P10828 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
HSD17B10 Q99714 1/20 0.44
CA12 O43570 2/20 0.44
CA7 P43166 2/20 0.44
CA9 Q16790 2/20 0.44
CA14 Q9ULX7 2/20 0.44
ITGA4 P13612 1/20 0.44
ITGB7 P26010 1/20 0.44
ANPEP P15144 1/20 0.44
POLB P06746 1/20 0.44
GAA P10253 1/20 0.43
RAB9A P51151 1/20 0.43
KLKB1 P03952 1/20 0.43
TSHR P16473 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3959739 0.81 ATM (0.68) ATML3MBTL1ALDH1A1THRBCYP2C9
SCHEMBL2375644 0.81 ATM (0.68) ATML3MBTL1ALDH1A1THRBCYP2C9
SCHEMBL2375646 0.81 ATM (0.68) ATML3MBTL1ALDH1A1THRBCYP2C9
Hydrochloric Acid SCHEMBL17822192 0.79 ATM (0.67) ATML3MBTL1ALDH1A1THRBCYP2C9
Hydrochloric Acid SCHEMBL1885086 0.79 ATM (0.67) ATML3MBTL1ALDH1A1THRBCYP2C9
Hydrochloric Acid SCHEMBL1885087 0.79 ATM (0.67) ATML3MBTL1ALDH1A1THRBCYP2C9
SCHEMBL7260951 0.79 ATM (0.62) ATML3MBTL1ALDH1A1THRBCYP2C9
SCHEMBL2375130 0.77 ATM (0.60) ATML3MBTL1ALDH1A1THRBCYP2C9
SCHEMBL2375126 0.77 ATM (0.60) ATML3MBTL1ALDH1A1THRBCYP2C9
SCHEMBL5887263 0.76 ATM (0.59) ATML3MBTL1ALDH1A1THRBCYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6403054-B1 MEDICAL DIAGNOSIS BRISTOL-MYERS SQUIBB PHARMA COMPANY 2002-06-11 US disclosed
EP-0984791-A1 TERNARY LIGAND COMPLEXES USEFUL AS RADIOPHARMACEUTICALS Du Pont Pharmaceuticals Company (US) 2000-03-15 EP disclosed
WO-1998053858-A1 TERNARY LIGAND COMPLEXES USEFUL AS RADIOPHARMACEUTICALS DU PONT PHARMACEUTICALS COMPANY (US) 1998-12-03 WO disclosed