Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28080270 | 0.84 | KDM4E (0.70) | KDM4ESMN1; SMN2KMT2AMEN1HPGD | |
| SCHEMBL2215871 | 0.82 | KDM4E (0.67) | KDM4ESMN1; SMN2RAB9AALDH1A1KMT2A | |
| SCHEMBL6360168 | 0.79 | KDM4E (0.77) | KDM4ESMN1; SMN2RAB9AKMT2ANPSR1 | |
| SCHEMBL10668907 | 0.78 | SMN1; SMN2 (0.61) | KDM4ESMN1; SMN2RAB9AALDH1A1KMT2A | |
| SCHEMBL1698848 | 0.78 | KMT2A (0.55) | KDM4ESMN1; SMN2RAB9AALDH1A1KMT2A | |
| SCHEMBL6359528 | 0.76 | KDM4E (0.88) | KDM4ESMN1; SMN2RAB9AALDH1A1KMT2A | |
| Hydrochloric Acid SCHEMBL11633248 | 0.76 | KDM4E (0.59) | KDM4ESMN1; SMN2RAB9AALDH1A1KMT2A | |
| Pyrazinamide SCHEMBL11617944 | 0.76 | ADORA3 (0.72) | KDM4ESMN1; SMN2RAB9AALDH1A1KMT2A | |
| SCHEMBL1428913 | 0.76 | KDM4E (0.63) | KDM4ESMN1; SMN2RAB9AKMT2ANPSR1 | |
| SCHEMBL13593756 | 0.76 | KDM4E (0.59) | KDM4ESMN1; SMN2RAB9AALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399607-B1 | ACTIVE OVER BROAD PH RANGE; TUBERCULOSIS | RESEARCH FOUNDATION-STATE UNIVERSITY OF NEW YORK | 2002-06-04 | — | — | US | disclosed |