Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.68 |
| ▸ | RAB9A | P51151 | 5/20 | 0.68 |
| ▸ | NPC1 | O15118 | 4/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | ALPL | P05186 | 3/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | GSK3A | P49840 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.60 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | KLK7 | P49862 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4851311 | 0.87 | ALPL (0.68) | MAPTRAB9ANPC1LMNAALPL | |
| SCHEMBL1924210 | 0.87 | ALPL (0.68) | MAPTRAB9ANPC1LMNAALPL | |
| SCHEMBL7724710 | 0.87 | MAPT (0.71) | MAPTRAB9ANPC1LMNAALPL | |
| SCHEMBL5229527 | 0.86 | MAPT (0.59) | MAPTRAB9ANPC1LMNAALPL | |
| SCHEMBL22728840 | 0.86 | MAPT (0.68) | MAPTRAB9ANPC1LMNAALPL | |
| SCHEMBL1924655 | 0.86 | GAA (0.63) | MAPTRAB9ANPC1LMNAALPL | |
| SCHEMBL20471653 | 0.86 | ALPL (0.51) | MAPTRAB9ANPC1LMNAALPL | |
| SCHEMBL1925116 | 0.86 | GAA (0.67) | MAPTRAB9ANPC1LMNAALPL | |
| SCHEMBL7719886 | 0.84 | MAPT (0.70) | MAPTRAB9ANPC1LMNAALPL | |
| SCHEMBL1924561 | 0.84 | MAPT (0.49) | MAPTRAB9ANPC1LMNAALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |