Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 2/20 | 0.35 |
| ▸ | RARB | P10826 | 10/20 | 0.34 |
| ▸ | RARG | P13631 | 8/20 | 0.34 |
| ▸ | RARA | P10276 | 7/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
| ▸ | MPL | P40238 | 1/20 | 0.33 |
| ▸ | ALB | P02768 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7730548 | 0.86 | RARA (0.39) | TTRRARBRARGRARAMPL | |
| SCHEMBL7730174 | 0.84 | RARA (0.43) | RARBRARGRARA | |
| SCHEMBL7616861 | 0.84 | RARA (0.43) | RARBRARGRARA | |
| SCHEMBL7730357 | 0.82 | RARA (0.39) | RARBRARGRARAKDM4EALDH1A1 | |
| SCHEMBL7720449 | 0.79 | RARA (0.42) | RARBRARGRARAMPLKDM4E | |
| SCHEMBL7720372 | 0.78 | RARA (0.39) | TTRRARBRARGRARAMPL | |
| SCHEMBL7724028 | 0.75 | RARA (0.41) | RARBRARGRARAKDM4EALDH1A1 | |
| SCHEMBL7625794 | 0.74 | RARA (0.43) | RARBRARGRARAKDM4EALDH1A1 | |
| SCHEMBL7618694 | 0.74 | RARA (0.49) | TTRRARBRARGRARAKDM4E | |
| SCHEMBL7619612 | 0.74 | RARA (0.40) | RARBRARGRARAMPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6358995-B1 | AGONIST FOR RETINOIC ACID RECEPTORS; CAN BE SUBSTITUTED FOR RETINOIC ACID AS PREVENTIVE AND THERAPEUTIC DRUGS FOR VARIOUS DISEASES OR CANCERS, SUCH AS ACUTE PROMYELOCYTIC LEUKEMIA. | EISAI CO., LTD. (JP) | 2002-03-19 | — | — | US | disclosed |
| US-6121309-A | SUCH AS 4-(2-(5-(7-FLUORO-4-TRIFLUOROMETHYLBENZOFURAN-2-YL)PYRROLYL)) BENZOIC ACID; RETINOIC ACID RECEPTOR AGONISM | EISAI CO., LTD. (JP) | 2000-09-19 | — | — | US | disclosed |
| US-6110959-A | A RETINOIC ACID RECEPTOR AGONIST | EISAI CO., LTD. (JP) | 2000-08-29 | — | — | US | disclosed |
| EP-0889032-A1 | FUSED-RING CARBOXYLIC ACID DERIVATIVES | Eisai Co., Ltd. (JP) | 1999-01-07 | — | — | EP | disclosed |