Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 6/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | HTR2A | P28223 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | HTR2C | P28335 | 3/20 | 0.41 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.40 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7726452 | 1.00 | NFE2L2 (0.55) | NFE2L2PTGS1PTGS2HTR2AKCNH2 | |
| SCHEMBL704659 | 0.84 | NFE2L2 (0.55) | NFE2L2 | |
| SCHEMBL704660 | 0.84 | NFE2L2 (0.55) | NFE2L2 | |
| SCHEMBL256688 | 0.80 | NFE2L2 (0.55) | NFE2L2PTGS1PTGS2HTR2AKCNH2 | |
| SCHEMBL2090395 | 0.80 | NFE2L2 (0.55) | NFE2L2PTGS1PTGS2HTR2AKCNH2 | |
| SCHEMBL2090393 | 0.80 | NFE2L2 (0.55) | NFE2L2PTGS1PTGS2HTR2AKCNH2 | |
| SCHEMBL5265029 | 0.80 | NFE2L2 (0.55) | NFE2L2PTGS1PTGS2HTR2AKCNH2 | |
| SCHEMBL2095520 | 0.78 | NFE2L2 (0.53) | NFE2L2PTGS1PTGS2HTR2AKCNH2 | |
| SCHEMBL2095515 | 0.76 | NFE2L2 (0.50) | NFE2L2PTGS1PTGS2HTR2AKCNH2 | |
| SCHEMBL2095517 | 0.76 | NFE2L2 (0.50) | NFE2L2PTGS1PTGS2HTR2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1142149-C | Novel pyridazine derivative and drug containing the same as active ingredient | ������������ʽ���� | 2004-03-17 | — | — | CN | disclosed |
| US-6403586-B1 | Pyridazine derivatives and drugs containing the same as the active ingredient | KOWA CO., LTD. (JP) | 2002-06-11 | — | — | US | disclosed |
| CN-1291979-A | Novel pyridazine derivatives and drugs containing same as active ingredient | KOWA CO (JP) | 2001-04-18 | — | — | CN | disclosed |
| EP-1061077-A1 | NOVEL PYRIDAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME AS THE ACTIVE INGREDIENT | Kowa Co., Ltd. (JP) | 2000-12-20 | — | — | EP | disclosed |