SCHEMBL772738

SCHEMBL772738

[CH2]CN1CCN(CC)CC1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 1/20 0.39
ALDH1A1 P00352 4/20 0.38
SMN1; SMN2 Q16637 3/20 0.37
KDM4E B2RXH2 2/20 0.37
GAA P10253 1/20 0.37
MAPT P10636 1/20 0.37
RAD52 P43351 1/20 0.37
GFER P55789 1/20 0.37
KMT2A Q03164 2/20 0.35
HSD11B1 P28845 1/20 0.34
CYP2D6 P10635 2/20 0.33
DUSP3 P51452 2/20 0.33
PTPN5 P54829 2/20 0.33
PTPN11 Q06124 2/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
STAT6 P42226 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL771417 0.92 KMT2A (0.39) CHRNA7ALDH1A1SMN1; SMN2KDM4EGAA
SCHEMBL84808 0.83 CHRNA7 (0.48) CHRNA7ALDH1A1SMN1; SMN2KDM4EGAA
SCHEMBL6657817 0.83 CHRNA7 (0.48) CHRNA7ALDH1A1SMN1; SMN2KDM4EGAA
SCHEMBL577415 0.83 CHRNA7 (0.48) CHRNA7ALDH1A1SMN1; SMN2KDM4EGAA
SCHEMBL11501665 0.83 ALDH1A1 (0.42) ALDH1A1SMN1; SMN2STAT6
SCHEMBL262312 0.83
SCHEMBL577052 0.83 CHRNA7 (0.48) CHRNA7ALDH1A1SMN1; SMN2KDM4EGAA
SCHEMBL23772 0.83
Iodide SCHEMBL11554007 0.79 CHRNA7 (0.46) CHRNA7ALDH1A1SMN1; SMN2KDM4EGAA
Hydrochloric Acid SCHEMBL14482129 0.79 CHRNA7 (0.46) CHRNA7ALDH1A1SMN1; SMN2KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 181 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4219495-A1 AHR MODULATORS Ideaya Biosciences, Inc. (US) 2023-08-02 EP claimed
EP-3749669-B1 AHR MODULATORS IDEAYA BIOSCIENCES INC (US) 2023-03-08 EP claimed
EP-3298011-B1 QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS PRINCIPIA BIOPHARMA INC (US) 2021-11-17 EP claimed
EP-3749669-A1 AHR MODULATORS Ideaya Biosciences, Inc. (US) 2020-12-16 EP claimed
CN-111683950-A AhR modulators 伊迪亚生物科学有限公司 2020-09-18 CN claimed
CN-107652289-B Substituted tricyclic compounds as FGFR inhibitors 因塞特控股公司 2020-07-21 CN claimed
WO-2019156987-A1 AhR MODULATORS IDEAYA BIOSCIENCES, INC. (US) 2019-08-15 WO claimed
US-10294260-B2 Tetracyclic anthraquinone derivatives TIANJIN HEMAY ONCOLOGY PHARMACEUTICAL CO., LTD. (CN) 2019-05-21 US claimed
US-20190127376-A1 SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS INCYTE CORPORATION 2019-05-02 US claimed
EP-3176170-B1 SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS INCYTE HOLDINGS CORP (US) 2018-11-14 EP claimed
EP-1838712-A1 PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS AstraZeneca AB (SE) 2007-10-03 EP claimed
WO-2006064196-A1 PYRAZOLOPYRIMIDINE COMPOUNDS AS ANTITUMOR AGENTS ASTRAZENECA AB (SE) 2006-06-22 WO claimed
EP-1647555-A1 THE C-GLYCOSYLISOFLAVONES HAVING ALKYLAMINOALKOXYL SUBSTITUENT, THE PREPARATION AND THE USE OF THE SAME Institute of Radiation Medicine Academy of Military Medical Sciences of the Pla (CN) 2006-04-19 EP claimed
US-4958024-A REACTION OF CARBAMATE SUBSTITUTED ACRYLIC ESTER, VASODILATORS, HYPOTENSIVE AGENTS BANYU PHARMACEUTICAL COMPANY, LTD. (JP) 1990-09-18 US claimed
US-4914227-A FOR VASODILATING AND HYPOTENSIVE AGENTS BANYU PHARMACEUTICAL COMPANY, LTD. (JP) 1990-04-03 US claimed
US-4739106-A VASODILATION, HYPOTENSIVE AGENTS BANYU PHARMACEUTICAL CO., LTD. (JP) 1988-04-19 US claimed
EP-0101023-B1 PROCESS FOR PREPARING 2-CARBAMOYLOXYALKYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND INTERMEDIATES USEFUL FOR THE PROCESS BANYU PHARMACEUTICAL CO., LTD. (JP) 1987-07-29 EP claimed
EP-0101023-A1 Process for preparing 2-carbamoyloxyalkyl-1,4-dihydropyridine derivatives and intermediates useful for the process BANYU PHARMACEUTICAL CO., LTD. (JP) 1984-02-22 EP claimed
US-4404378-A HYPOTENSIVE AGENTS; VASODILATION BANYU PHARMACEUTICAL CO., LTD. (JP) 1983-09-13 US claimed
EP-0063747-A1 2-Substituted or unsubstituted aminocarbonyloxyalkyl-1,4-dihydropyridines BANYU PHARMACEUTICAL CO., LTD. (JP) 1982-11-03 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10294260-B2 Tetracyclic anthraquinone derivatives H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, F12, ANTXR2 CHRNA7 4592/4885ALDH1A1 736/4885SMN1; SMN2 2232/4885
US-20190127376-A1 SUBSTITUTED TRICYCLIC COMPOUNDS AS FGFR INHIBITORS FGFR3, FGFR1, FGFR2 CHRNA7 4883/4885ALDH1A1 586/4885SMN1; SMN2 4636/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.