SCHEMBL7728049

SCHEMBL7728049

CSc1ncn2cc(C3=C(C(=O)OCOC(=O)OC4CCCCC4)N4C(=O)[C@H]([C@@H](C)O)[C@H]4[C@H]3C)sc12

nearest known ligand 0.36

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FAP Q12884 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7722474 0.91 FAP (0.36) FAP
SCHEMBL7728416 0.90 FAP (0.36) FAP
SCHEMBL7728031 0.90 FAP (0.35) FAP
SCHEMBL7732125 0.89 FAP (0.35) FAP
SCHEMBL7730433 0.88 FAP (0.34) FAP
SCHEMBL7728776 0.88 FAP (0.35) FAP
SCHEMBL7728223 0.88
SCHEMBL7729782 0.88 FAP (0.38) FAP
SCHEMBL7730821 0.86 FAP (0.38) FAP
SCHEMBL7734763 0.86 FAP (0.34) FAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6458780-B1 IMIDAZO(5,1-B)THIAZOLE GROUP AT THE 2-POSITION ON THE CARBAPENEM RING HAVE HIGH ANTI-MICROBIAL ACTIVITIES AGAINST .BETA.-LACTAMASE PRODUCING BACTERIA, MRSA, RESISTANT-PSEUDOMONAS AERUGINOSA, PRSP, ENTEROCOCCI, AND MEIJI SEIKA KAISHA, LTD. (JP) 2002-10-01 US disclosed