Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 4/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7728349 | 1.00 | BTK (0.38) | BTKACESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7728341 | 1.00 | BTK (0.38) | BTKACESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7727553 | 1.00 | BTK (0.38) | BTKACESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL7729316 | 0.90 | MMP2 (0.36) | EPHX1CYP2C9HSD11B1CYP1A2POLB | |
| SCHEMBL7727758 | 0.90 | MMP2 (0.36) | EPHX1CYP2C9HSD11B1CYP1A2POLB | |
| SCHEMBL7727763 | 0.90 | MMP2 (0.36) | EPHX1CYP2C9HSD11B1CYP1A2POLB | |
| SCHEMBL25235410 | 0.82 | BTK (0.54) | BTKSMN1; SMN2KMT2AGAACYP2C9 | |
| SCHEMBL7736016 | 0.82 | BTK (0.54) | BTKSMN1; SMN2KMT2AGAACYP2C9 | |
| SCHEMBL7722234 | 0.82 | BTK (0.54) | BTKSMN1; SMN2KMT2AGAACYP2C9 | |
| SCHEMBL7729066 | 0.82 | BTK (0.54) | BTKSMN1; SMN2KMT2AGAACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |