Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 11/20 | 0.37 |
| ▸ | PEPD | P12955 | 4/20 | 0.36 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.36 |
| ▸ | ANPEP | P15144 | 6/20 | 0.36 |
| ▸ | XPNPEP1 | Q9NQW7 | 2/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7727563 | 0.90 | HTRA1 (0.39) | MMP2HTRA1ANPEPCYP1A2POLB | |
| SCHEMBL7731684 | 0.79 | BTK (0.46) | MMP2ANPEPNR1H2NR1H3PTPN1 | |
| SCHEMBL13938227 | 0.79 | MMP2 (0.47) | MMP2ANPEPNR1H2NR1H3PTPN1 | |
| SCHEMBL7727313 | 0.79 | BTK (0.46) | MMP2ANPEPNR1H2NR1H3PTPN1 | |
| SCHEMBL13938226 | 0.79 | MMP2 (0.47) | MMP2ANPEPNR1H2NR1H3PTPN1 | |
| SCHEMBL7727315 | 0.79 | BTK (0.46) | MMP2ANPEPNR1H2NR1H3PTPN1 | |
| SCHEMBL7727763 | 0.77 | MMP2 (0.36) | MMP2PEPDANPEPXPNPEP1NR1H2 | |
| SCHEMBL7727758 | 0.77 | MMP2 (0.36) | MMP2PEPDANPEPXPNPEP1NR1H2 | |
| SCHEMBL7729316 | 0.77 | MMP2 (0.36) | MMP2PEPDANPEPXPNPEP1NR1H2 | |
| SCHEMBL12651618 | 0.77 | MMP2 (0.43) | MMP2ANPEPNR1H2NR1H3PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |