SCHEMBL7729417

SCHEMBL7729417

Cc1cc(C)c(C(=O)OCOC(=O)C2=C(c3cn4cnc(S(C)(=O)=O)c4s3)[C@H](C)[C@@H]3[C@@H]([C@@H](C)O)C(=O)N23)c(C)c1

nearest known ligand 0.34

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FAP Q12884 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7731772 0.89 FAP (0.33) FAP
SCHEMBL7731962 0.88 FAP (0.35) FAP
SCHEMBL7722622 0.88 FAP (0.45) FAP
SCHEMBL7729901 0.86 FAP (0.34) FAP
SCHEMBL7722242 0.86 FAP (0.34) FAP
SCHEMBL7730735 0.85 FAP (0.35) FAP
SCHEMBL7722337 0.85 FAP (0.35) FAP
SCHEMBL7729742 0.84 FAP (0.34) FAP
SCHEMBL7729152 0.84 FAP (0.34) FAP
SCHEMBL7734630 0.84 FAP (0.36) FAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6458780-B1 IMIDAZO(5,1-B)THIAZOLE GROUP AT THE 2-POSITION ON THE CARBAPENEM RING HAVE HIGH ANTI-MICROBIAL ACTIVITIES AGAINST .BETA.-LACTAMASE PRODUCING BACTERIA, MRSA, RESISTANT-PSEUDOMONAS AERUGINOSA, PRSP, ENTEROCOCCI, AND MEIJI SEIKA KAISHA, LTD. (JP) 2002-10-01 US disclosed