Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | XBP1 | P17861 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 4/20 | 0.42 |
| ▸ | CNR1 | P21554 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7726525 | 0.81 | POLB (0.56) | EPHX2NPC1POLBRAB9AMAPT | |
| SCHEMBL7728992 | 0.81 | POLB (0.56) | EPHX2NPC1POLBRAB9AMAPT | |
| SCHEMBL7728996 | 0.81 | POLB (0.56) | EPHX2NPC1POLBRAB9AMAPT | |
| SCHEMBL7722250 | 0.81 | POLB (0.46) | EPHX2NPC1POLBRAB9AMAPT | |
| SCHEMBL7722254 | 0.81 | POLB (0.46) | EPHX2NPC1POLBRAB9AMAPT | |
| SCHEMBL7734120 | 0.80 | NPC1 (0.52) | NPC1POLBRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7734121 | 0.80 | NPC1 (0.52) | NPC1POLBRAB9AMAPTSMN1; SMN2 | |
| SCHEMBL7303267 | 0.79 | MCL1 (0.47) | POLBMCL1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL25097911 | 0.77 | NR1H2 (0.47) | POLBMCL1ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL6847935 | 0.77 | NR1H2 (0.47) | POLBMCL1ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |