Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 7/20 | 0.35 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7732306 | 0.94 | PLCG1 (0.35) | ELANEPLCG1L3MBTL1HTR2AALDH1A1 | |
| SCHEMBL7731948 | 0.93 | PLCG1 (0.34) | ELANEPLCG1L3MBTL1HTR2AALDH1A1 | |
| SCHEMBL7722496 | 0.92 | ALDH1A1 (0.40) | ELANEPLCG1L3MBTL1HTR2AALDH1A1 | |
| SCHEMBL7727955 | 0.91 | PLCG1 (0.34) | ELANEPLCG1L3MBTL1HTR2AALDH1A1 | |
| SCHEMBL7727973 | 0.91 | ALDH1A1 (0.36) | ELANEPLCG1L3MBTL1HTR2AALDH1A1 | |
| SCHEMBL7729895 | 0.91 | PLCG1 (0.34) | ELANEPLCG1L3MBTL1HTR2AALDH1A1 | |
| SCHEMBL7636272 | 0.90 | PLCG1 (0.35) | ELANEPLCG1L3MBTL1HTR2AALDH1A1 | |
| SCHEMBL7728957 | 0.90 | PLCG1 (0.37) | ELANEPLCG1L3MBTL1HTR2AHTT | |
| SCHEMBL7722355 | 0.89 | ALDH1A1 (0.34) | ELANEPLCG1HTR2AALDH1A1 | |
| SCHEMBL7722446 | 0.89 | ELANE (0.36) | ELANEPLCG1L3MBTL1HTR2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458780-B1 | IMIDAZO(5,1-B)THIAZOLE GROUP AT THE 2-POSITION ON THE CARBAPENEM RING HAVE HIGH ANTI-MICROBIAL ACTIVITIES AGAINST .BETA.-LACTAMASE PRODUCING BACTERIA, MRSA, RESISTANT-PSEUDOMONAS AERUGINOSA, PRSP, ENTEROCOCCI, AND | MEIJI SEIKA KAISHA, LTD. (JP) | 2002-10-01 | — | — | US | disclosed |