SCHEMBL7730388

SCHEMBL7730388

CCc1ccc(C(F)(F)Oc2ccc(CCc3ccc(OC(F)F)cc3)cc2)cc1

nearest known ligand 0.40

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
DAO P14920 2/20 0.40
PPARG P37231 2/20 0.37
PPARA Q07869 2/20 0.37
KMT2A Q03164 2/20 0.35
LMNA P02545 1/20 0.35
POLB P06746 1/20 0.35
TSHR P16473 1/20 0.35
SLC6A4 P31645 2/20 0.34
SLC6A3 Q01959 2/20 0.34
EPHX2 P34913 1/20 0.33
NR1H4 Q96RI1 1/20 0.33
HTT P42858 1/20 0.33
GPR84 Q9NQS5 1/20 0.33
RXRA P19793 1/20 0.33
GRIN1 Q05586 1/20 0.33
GRIN2B Q13224 1/20 0.33
MEN1 O00255 1/20 0.33
MAPK1 P28482 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7730882 0.96 PPARG (0.39) DAOPPARGPPARALMNAPOLB
SCHEMBL7730604 0.96 PPARG (0.39) DAOPPARGPPARALMNAPOLB
SCHEMBL7729751 0.91 DAO (0.40) DAOPPARGPPARAKMT2ALMNA
SCHEMBL7731001 0.90 PPARG (0.40) DAOPPARGPPARAKMT2ALMNA
SCHEMBL7732775 0.90 PPARG (0.40) DAOPPARGPPARAKMT2ALMNA
SCHEMBL7732522 0.89 DAO (0.39) DAOPPARGPPARAKMT2ALMNA
SCHEMBL7734866 0.88 PPARA (0.42) DAOPPARAKMT2ALMNASLC6A4
SCHEMBL7733320 0.87 PPARA (0.38) DAOPPARAKMT2ALMNAPOLB
SCHEMBL7730399 0.87 PPARA (0.38) DAOPPARAKMT2ALMNAPOLB
SCHEMBL7729682 0.86 TSHR (0.45) DAOLMNATSHRSLC6A4SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed