SCHEMBL7730617

SCHEMBL7730617

CCCCC[C@H]1CC[C@H](CCc2ccc(C(F)(F)Oc3cc(F)c(C(F)(F)F)c(F)c3)c(F)c2)CC1

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.32
CYP2C8 P10632 1/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
S1PR3 Q99500 1/20 0.32
BCHE P06276 1/20 0.30
S1PR1 P21453 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7730621 1.00 CYP3A4 (0.32) CYP3A4CYP2C8CYP2D6CYP2C9CYP2C19
SCHEMBL7729307 0.97 BCHE (0.31) BCHE
SCHEMBL7729303 0.97 BCHE (0.31) BCHE
SCHEMBL7731393 0.93 DAO (0.31)
SCHEMBL7731391 0.93 DAO (0.31)
SCHEMBL7731457 0.92 CYP3A4 (0.33) CYP3A4CYP2C8CYP2D6CYP2C9CYP2C19
SCHEMBL7731452 0.92 CYP3A4 (0.33) CYP3A4CYP2C8CYP2D6CYP2C9CYP2C19
SCHEMBL7731269 0.90 DAO (0.31)
SCHEMBL7731274 0.90 DAO (0.31)
SCHEMBL7722786 0.89 CYP3A4 (0.32) CYP3A4CYP2C8CYP2D6CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786445-B1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORP (JP) 2002-07-17 EP disclosed
US-5858270-A Difluorooxymethane derivative and liquid crystal composition CHISSO CORPORATION (JP) 1999-01-12 US disclosed
EP-0786445-A1 DIFLUOROXYMETHANE DERIVATIVE AND LIQUID CRYSTAL COMPOSITION CHISSO CORPORATION (JP) 1997-07-30 EP disclosed