Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 20/20 | 0.44 |
| ▸ | BCL2 | P10415 | 5/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8149637 | 1.00 | MCL1 (0.44) | MCL1BCL2BCL2L1 | |
| SCHEMBL7729856 | 0.88 | MCL1 (0.44) | MCL1 | |
| SCHEMBL7730725 | 0.85 | MCL1 (0.43) | MCL1BCL2BCL2L1 | |
| SCHEMBL7722106 | 0.79 | MCL1 (0.45) | MCL1 | |
| SCHEMBL7722150 | 0.79 | MCL1 (0.50) | MCL1BCL2BCL2L1 | |
| SCHEMBL7722217 | 0.76 | MCL1 (0.50) | MCL1BCL2BCL2L1 | |
| SCHEMBL14555378 | 0.75 | USP30 (0.49) | MCL1 | |
| SCHEMBL15723659 | 0.75 | USP30 (0.49) | MCL1 | |
| SCHEMBL17152834 | 0.74 | BCL2 (0.33) | MCL1BCL2BCL2L1 | |
| SCHEMBL9020884 | 0.74 | BCL2 (0.33) | MCL1BCL2BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399629-B1 | PYRROLIDINES AND PIPERIDINES FOR TREATING MICROBIAL INFECTIONS BY REDUCING EXPORT OF COADMINISTERED ANTIMICROBIAL AGENT OR COMPOUND SYNTHESIZED BY MICROBES FOR THEIR GROWTH; REDUCING IN VIVO AVAILABILITY | MICROCIDE PHARMACEUTICALS, INC. | 2002-06-04 | — | — | US | disclosed |