Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7723306 | 0.74 | LMNA (0.55) | HTTMAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL8122548 | 0.73 | DRD4 (0.55) | HTTMAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL7731046 | 0.72 | LMNA (0.56) | HTTMAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL6427625 | 0.72 | MAPT (0.65) | HTTMAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL7734279 | 0.72 | LMNA (0.56) | HTTMAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL3156396 | 0.71 | MEN1 (0.77) | HTTMAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL7732681 | 0.71 | MEN1 (0.46) | LMNAMEN1KMT2ASLC6A2SLC6A4 | |
| SCHEMBL7731296 | 0.71 | DRD4 (0.65) | HTTMAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL17628468 | 0.70 | KMT2A (0.70) | HTTMAPTLMNASMN1; SMN2MAPK1 | |
| SCHEMBL5170576 | 0.70 | HTT (0.75) | HTTMAPTLMNASMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407122-B1 | NEUROPROTECTIVE AGENTS, ANTIISCHEMIC, AND HYPERGLYCEMIC AGENTS; HUNTINGTON*S, PARKINSON*S, AND ALZHEIMER*S DISEASE;AMYOTROPHIC LATERAL SCLEROSIS TREATMENT; NERVOUS SYSTEM AND BRAIN DISORDERS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-06-18 | — | — | US | disclosed |