SCHEMBL7732680

SCHEMBL7732680

CSc1ncn2cc(C3=C(C(=O)OCOC(=O)c4cc(C)cc(C)c4)N4C(=O)[C@H]([C@@H](C)O)[C@H]4[C@H]3C)sc12

nearest known ligand 0.36

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
FAP Q12884 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7722211 0.93 FAP (0.36) FAP
SCHEMBL7731962 0.92 FAP (0.35) FAP
SCHEMBL7730149 0.90 FAP (0.36) FAP
SCHEMBL7729782 0.90 FAP (0.38) FAP
SCHEMBL7722489 0.89 FAP (0.35) FAP
SCHEMBL7734749 0.89 FAP (0.34) FAP
SCHEMBL7730301 0.89 FAP (0.34) FAP
SCHEMBL7729293 0.88 FAP (0.47) FAP
SCHEMBL7734482 0.88 FAP (0.36) FAP
SCHEMBL7731893 0.88 FAP (0.34) FAP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6458780-B1 IMIDAZO(5,1-B)THIAZOLE GROUP AT THE 2-POSITION ON THE CARBAPENEM RING HAVE HIGH ANTI-MICROBIAL ACTIVITIES AGAINST .BETA.-LACTAMASE PRODUCING BACTERIA, MRSA, RESISTANT-PSEUDOMONAS AERUGINOSA, PRSP, ENTEROCOCCI, AND MEIJI SEIKA KAISHA, LTD. (JP) 2002-10-01 US disclosed
EP-1101766-A1 NOVEL CARBAPENEM DERIVATIVES MEIJI SEIKA KAISHA LTD. (JP) 2001-05-23 EP disclosed