Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | PI4KA | P42356 | 1/20 | 0.54 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.54 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.54 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.54 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.50 |
| ▸ | P2RX1 | P51575 | 2/20 | 0.50 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.50 |
| ▸ | AMD1 | P17707 | 2/20 | 0.46 |
| ▸ | TYMP | P19971 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7732794 | 1.00 | RXFP1 (0.54) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL6659324 | 0.87 | RXFP1 (0.59) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL6659329 | 0.87 | RXFP1 (0.59) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1795964 | 0.85 | RXFP1 (0.54) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1795283 | 0.85 | RXFP1 (0.54) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1795275 | 0.85 | RXFP1 (0.54) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1795966 | 0.85 | RXFP1 (0.54) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL20524284 | 0.84 | P2RX3 (0.58) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1796531 | 0.83 | RXFP1 (0.69) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1798145 | 0.83 | RXFP1 (0.57) | RXFP1PI4KAPI4K2BPI4K2API4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407076-B1 | ANTIISCHEMIC, ANTILIPOLYTIC, ANTICONVULSANT AND HYPOTENSIVE AGENTS; CARDIOVASCULAR AND NERVOUS SYSTEM DISORDERS; ATHEROSCLEROSIS | SMITHKLINE BEECHAM CORPORATION | 2002-06-18 | — | — | US | disclosed |
| EP-1027363-A2 | ADENOSINE A1-RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999024450-A2 | ADENSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |