SCHEMBL7733103

SCHEMBL7733103

C/C=C/C=C/COc1ccc(-c2ccc(OC/C=C/C)cc2)cc1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 1/20 0.35
MAOB P27338 1/20 0.34
CYP3A4 P08684 3/20 0.33
CYP2D6 P10635 2/20 0.33
NQO1 P15559 1/20 0.32
HDAC3 O15379 1/20 0.32
HDAC4 P56524 1/20 0.32
HDAC1 Q13547 1/20 0.32
HDAC7 Q8WUI4 1/20 0.32
HDAC2 Q92769 1/20 0.32
HDAC10 Q969S8 1/20 0.32
HDAC11 Q96DB2 1/20 0.32
HDAC8 Q9BY41 1/20 0.32
HDAC6 Q9UBN7 1/20 0.32
HDAC9 Q9UKV0 1/20 0.32
HDAC5 Q9UQL6 1/20 0.32
LSS P48449 1/20 0.32
AAK1 Q2M2I8 2/20 0.31
MMP1 P03956 1/20 0.31
MMP13 P45452 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7734386 0.96 AOC3 (0.37) AOC3MAOBCYP3A4CYP2D6NQO1
SCHEMBL7734389 0.96 AOC3 (0.37) AOC3MAOBCYP3A4CYP2D6NQO1
SCHEMBL7731780 0.89 ESR2 (0.41) MAOBCYP3A4
SCHEMBL7731774 0.89 NQO1 (0.48) CYP3A4CYP2D6NQO1CYP1A2CYP2C9
SCHEMBL7723533 0.88 LSS (0.39) MAOBLSSCHRNA7
SCHEMBL7731759 0.88 CYP1A2 (0.36) MAOBCYP2D6CYP1A2CYP2C19
SCHEMBL7731756 0.88 CYP1A2 (0.36) MAOBCYP2D6CYP1A2CYP2C19
SCHEMBL7723537 0.88 LSS (0.39) MAOBLSSCHRNA7
SCHEMBL7723546 0.88 NPSR1 (0.36) MAOB
SCHEMBL7723540 0.88 NPSR1 (0.36) MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0929508-B1 LIQUID CRYSTALLINE (E,E)-BUTADIENE COMPOUNDS AND MIXTURES AND DEVICES CONTAINING SUCH COMPOUNDS QINETIQ LTD (GB) 2002-03-20 EP disclosed
US-6106908-A OPTICAL APPARATUS WITH LIQUID CRYSTAL COMPOUNDS THE SECRETARY OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND (GB) 2000-08-22 US disclosed