SCHEMBL7734389

SCHEMBL7734389

CC=CC=CCOc1ccc(-c2ccc(OCC=CC=CC)cc2)cc1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 1/20 0.37
MAOB P27338 1/20 0.35
CYP3A4 P08684 4/20 0.35
CYP2D6 P10635 3/20 0.35
NQO1 P15559 1/20 0.34
LSS P48449 1/20 0.33
AAK1 Q2M2I8 2/20 0.33
CYP19A1 P11511 2/20 0.33
CYP2C9 P11712 2/20 0.33
CYP2C19 P33261 2/20 0.33
CYP1A2 P05177 1/20 0.33
CHRNB2 P17787 1/20 0.32
CHRNB4 P30926 1/20 0.32
CHRNA3 P32297 1/20 0.32
CHRNA7 P36544 1/20 0.32
CHRNA4 P43681 1/20 0.32
XDH P47989 1/20 0.31
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7734386 1.00 AOC3 (0.37) AOC3MAOBCYP3A4CYP2D6NQO1
SCHEMBL7733103 0.96 AOC3 (0.35) AOC3MAOBCYP3A4CYP2D6NQO1
SCHEMBL7733105 0.96 AOC3 (0.35) AOC3MAOBCYP3A4CYP2D6NQO1
SCHEMBL7731783 0.93 ESR2 (0.41) MAOBCYP3A4KDM4EALDH1A1MAPT
SCHEMBL7731774 0.93 NQO1 (0.48) CYP3A4CYP2D6NQO1CYP2C9CYP2C19
SCHEMBL7731776 0.93 NQO1 (0.48) CYP3A4CYP2D6NQO1CYP2C9CYP2C19
SCHEMBL7731780 0.93 ESR2 (0.41) MAOBCYP3A4KDM4EALDH1A1MAPT
SCHEMBL7731756 0.91 CYP1A2 (0.36) MAOBCYP2D6CYP2C19CYP1A2
SCHEMBL7723533 0.91 LSS (0.39) MAOBLSSCHRNA7KDM4EALDH1A1
SCHEMBL7723546 0.91 NPSR1 (0.36) MAOBMAPTMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0929508-B1 LIQUID CRYSTALLINE (E,E)-BUTADIENE COMPOUNDS AND MIXTURES AND DEVICES CONTAINING SUCH COMPOUNDS QINETIQ LTD (GB) 2002-03-20 EP disclosed
US-6106908-A OPTICAL APPARATUS WITH LIQUID CRYSTAL COMPOUNDS THE SECRETARY OF STATE FOR DEFENCE IN HER BRITANNIC MAJESTY'S GOVERNMENT OF THE UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND (GB) 2000-08-22 US disclosed