Aziridine

Aziridine

SCHEMBL7733248

C1CN1.CCC(O)C[N+](C)(C)C

nearest known ligand 0.38

Full drug profile on Sugi Atlas →

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
SLC22A16 Q86VW1 1/20 0.38
MAPT P10636 1/20 0.38
TSHR P16473 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10274560 0.87
SCHEMBL890513 0.87
Water SCHEMBL1358117 0.84 MAPT (0.44) SLC22A16MAPTTSHR
SCHEMBL16405718 0.77 MAPT (0.44) SLC22A16MAPTTSHR
Formic Acid SCHEMBL11662526 0.75 MAPT (0.43) SLC22A16MAPTTSHR
Water SCHEMBL11452058 0.75 TSHR (0.43) SLC22A16MAPTTSHR
Formic Acid SCHEMBL11662523 0.73 SLC22A16 (0.46) SLC22A16MAPTTSHR
Prolonium SCHEMBL1649967 0.71 MAPT (0.52) SLC22A16MAPTTSHR
SCHEMBL17430801 0.70 MAPT (0.37) SLC22A16MAPTTSHR
SCHEMBL12192711 0.69 PSMD14 (0.35) SLC22A16MAPTTSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11154550-B2 Treatment for neurodegeneration THE UNIVERSITY OF BIRMINGHAM (GB) 2021-10-26 US disclosed
EP-2900236-B2 TREATMENT OF WOLFRAM SYNDROME-RELATED NEURODEGENERATION UNIV BIRMINGHAM (GB) 2021-09-29 EP disclosed
EP-2900236-B1 TREATMENT OF WOLFRAM SYNDROME-RELATED NEURODEGENERATION UNIV BIRMINGHAM (GB) 2019-01-16 EP disclosed
US-20150246037-A1 TREATMENT FOR NEURODEGENERATION THE UNIVERSITY OF BIRMINGHAM (GB) 2015-09-03 US disclosed
US-6353015-B1 INDOLE DERIVATIVES FOR NERVOUS SYSTEM DISORDERS ST. ELIZABETH'S MEDICAL CENTER 2002-03-05 US disclosed
WO-2000012045-A2 METHOD FOR TREATING NEURODEGENERATIVE DISORDERS ST. ELIZABETH'S MEDICAL CENTER OF BOSTON, INC. (US) 2000-03-09 WO disclosed
EP-0625196-A1 NEUROTROPHIC FACTOR HOUSTON BIOTECHNOLOGY INCORPORATED (US) 1994-11-23 EP disclosed
WO-1994012634-A1 NEUROTROPHIC FACTOR HOUSTON BIOTECHNOLOGY INCORPORATED (US) 1994-06-09 WO disclosed
EP-0178743-B1 NOVEL TRITIUM LABELLED N-MUSTARD TYPE COMPOUNDS AND A PROCESS FOR THEIR PRODUCTION UNIVERSITY OF PITTSBURGH (US) 1990-05-23 EP disclosed
US-4795627-A AZIRIDINIUM ANALOG USED TO EVALUATE THE MECHANISM OF NEUROTRANSMITTER REGULATION UNIVERSITY OF PITTSBURGH (US) 1989-01-03 US disclosed