Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MMP2 | P08253 | 1/20 | 0.46 |
| ▸ | MMP12 | P39900 | 1/20 | 0.46 |
| ▸ | PTPN7 | P35236 | 3/20 | 0.42 |
| ▸ | HMGCR | P04035 | 1/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7739092 | 0.88 | POLB (0.52) | POLBRECQLFFAR1FFAR4MAPT | |
| SCHEMBL10669167 | 0.77 | POLB (0.42) | POLBRECQLFFAR1FFAR4KMT2A | |
| SCHEMBL10665061 | 0.77 | POLB (0.42) | POLBRECQLFFAR1FFAR4KMT2A | |
| SCHEMBL10669748 | 0.75 | KCNH2 (0.42) | POLBRECQLFFAR1FFAR4TDP1 | |
| SCHEMBL10692511 | 0.74 | TDP1 (0.43) | POLBRECQLTDP1 | |
| SCHEMBL2637097 | 0.73 | ACACB (0.52) | POLBMEN1KMT2ATDP1 | |
| SCHEMBL14822942 | 0.72 | POLB (0.56) | POLBRECQLFFAR1FFAR4TDP1 | |
| SCHEMBL25456552 | 0.72 | FFAR1 (0.74) | FFAR1FFAR4MMP2MMP12PTPN7 | |
| SCHEMBL23752580 | 0.71 | POLB (0.64) | POLBRECQLMEN1KMT2ATDP1 | |
| SCHEMBL30143434 | 0.71 | MMP2 (0.72) | FFAR1FFAR4MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7790744-B2 | Cyclic peptide antifungal agents and process for preparation thereof | ELI LILLY AND COMPANY (US) | 2010-09-07 | — | — | US | disclosed |
| US-6743777-B1 | TRISPHENYL ACYL DERIVATIVES OF THE ECHINOCANDIN CLASS; CANDIDA ALBICANS; ANTIFUNGAL AND ANTIPARASITIC; CYCLIC HEXAPEPTIDES HAVING UNIQUE SIDE CHAIN ACYL GROUP | ELI LILLY AND COMPANY | 2004-06-01 | — | — | US | disclosed |