Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.57 |
| ▸ | DRD4 | P21917 | 4/20 | 0.57 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.57 |
| ▸ | HTR7 | P34969 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HTR1B | P28222 | 1/20 | 0.57 |
| ▸ | HTR2B | P41595 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL989581 | 0.90 | HTR1A (0.69) | HTR1AADRA1ADRD4ADRA1BADRA1D | |
| SCHEMBL7612682 | 0.90 | HTR1A (0.56) | HTR1AADRA1ADRD4ADRA1BADRA1D | |
| SCHEMBL7736577 | 0.88 | HTR1A (0.54) | HTR1AADRA1ADRD4ADRA1BADRA1D | |
| SCHEMBL7611697 | 0.88 | HTR1A (0.54) | HTR1AADRA1ADRD4ADRA1BADRA1D | |
| SCHEMBL7607814 | 0.88 | HTR1A (0.54) | HTR1AADRA1ADRD4ADRA1BADRA1D | |
| SCHEMBL6312809 | 0.87 | HTR1A (0.64) | HTR1AADRA1ADRD4ADRA1BADRA1D | |
| SCHEMBL6312815 | 0.87 | HTR1A (0.64) | HTR1AADRA1ADRD4ADRA1BADRA1D | |
| SCHEMBL7613972 | 0.85 | HTR1A (0.57) | HTR1AADRA1ADRD4ADRA1BADRA1D | |
| SCHEMBL7608873 | 0.84 | HTR1A (0.59) | HTR1AADRA1ADRD4ADRA1BADRA1D | |
| SCHEMBL7955093 | 0.83 | HTR1A (0.81) | HTR1AADRA1ADRD4ADRA1BADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399614-B1 | TREATING NEUROMUSCULAR DYSFUNCTION OF LOWER URINARY TRACT VIA PERIPHERAL OR CENTRAL NERVOUS SYSTEM; SEROTONIN RECEPTOR ANTAGONIST | RECORDATI S.A. CHEMICAL AND PHARMACEUTICAL COMPANY (CH) | 2002-06-04 | — | — | US | disclosed |