Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.64 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.64 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.64 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.63 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.63 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.63 |
| ▸ | SLC29A1 | Q99808 | 2/20 | 0.63 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.63 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.59 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13384988 | 0.95 | ADORA1 (0.71) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL4649323 | 0.94 | PI4KA (0.68) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL12200089 | 0.93 | ADORA3 (0.69) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL15144301 | 0.93 | ADORA3 (0.69) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL5507191 | 0.93 | ADORA3 (0.69) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL7735031 | 0.93 | ADORA3 (0.69) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL5508361 | 0.92 | TSHR (0.70) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL5993960 | 0.90 | ADORA3 (0.64) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL15425648 | 0.88 | PI4KA (0.62) | PI4KAPI4K2BPI4K2API4KBADORA3 | |
| SCHEMBL15426679 | 0.88 | PI4KA (0.62) | PI4KAPI4K2BPI4K2API4KBADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407076-B1 | ANTIISCHEMIC, ANTILIPOLYTIC, ANTICONVULSANT AND HYPOTENSIVE AGENTS; CARDIOVASCULAR AND NERVOUS SYSTEM DISORDERS; ATHEROSCLEROSIS | SMITHKLINE BEECHAM CORPORATION | 2002-06-18 | — | — | US | disclosed |
| EP-1027363-A2 | ADENOSINE A1-RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999024450-A2 | ADENSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |