Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 20/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 20/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 20/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 20/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6673641 | 0.93 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6679227 | 0.93 | PDE4A (0.49) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6673648 | 0.93 | PDE4A (0.52) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6675012 | 0.86 | PDE4A (0.63) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6674993 | 0.83 | ALDH1A1 (0.45) | — | |
| SCHEMBL7740525 | 0.83 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6673308 | 0.81 | SIRT2 (0.45) | — | |
| SCHEMBL6154427 | 0.80 | PDE4B (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6673654 | 0.79 | PDE4B (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7740521 | 0.78 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6413975-B1 | DISEASES WITH HIGH LEVELS OF INFLAMMATORY CYTOKINES; ASTHMA; ALLERGIES; INFLAMMATION; DEPRESSION; ALZHEIMER'S DISEASE; VASCULAR AND MULTI-IN-FARCT DEMENTIA | EURO-CELTIQUE, S.A. (LU) | 2002-07-02 | — | — | US | disclosed |