Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 2/20 | 0.77 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.77 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.77 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.51 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.51 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.51 |
| ▸ | SLC29A1 | Q99808 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.49 |
| ▸ | AMD1 | P17707 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.47 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30942645 | 1.00 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL12629188 | 1.00 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL1795588 | 1.00 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL66731 | 1.00 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL91054 | 1.00 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL1757060 | 1.00 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL17568785 | 1.00 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL15395424 | 1.00 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL21882960 | 1.00 | PI4KA (0.77) | PI4KAPI4K2BPI4K2API4KBALDH1A1 | |
| SCHEMBL5672710 | 0.90 | PI4KA (0.63) | PI4KAPI4K2BPI4K2API4KBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012082436-A2 | MODULATORS OF HISTONE METHYLTRANSFERASE, AND METHODS OF USE THEREOF | Epizyme, Inc. (US) | 2012-06-21 | — | — | WO | disclosed |
| US-6407076-B1 | ANTIISCHEMIC, ANTILIPOLYTIC, ANTICONVULSANT AND HYPOTENSIVE AGENTS; CARDIOVASCULAR AND NERVOUS SYSTEM DISORDERS; ATHEROSCLEROSIS | SMITHKLINE BEECHAM CORPORATION | 2002-06-18 | — | — | US | disclosed |
| EP-1027363-A2 | ADENOSINE A1-RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 2000-08-16 | — | — | EP | disclosed |
| WO-1999024450-A2 | ADENSINE A1 RECEPTOR AGONISTS | GLAXO GROUP LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |