Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.60 |
| ▸ | CTSK | P43235 | 9/20 | 0.51 |
| ▸ | CTRB1 | P17538 | 2/20 | 0.50 |
| ▸ | CTSS | P25774 | 4/20 | 0.48 |
| ▸ | CTSL | P07711 | 4/20 | 0.48 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.47 |
| ▸ | CTSB | P07858 | 2/20 | 0.46 |
| ▸ | ELANE | P08246 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7555566 | 0.85 | CTSK (0.59) | SYKCTSKCTSSCTSLPSMB5 | |
| SCHEMBL7553408 | 0.85 | CTSK (0.59) | SYKCTSKCTSSCTSLPSMB5 | |
| SCHEMBL2723504 | 0.83 | CTSK (0.62) | CTSKCTRB1CTSSCTSLPSMB5 | |
| SCHEMBL14923444 | 0.83 | CTSK (0.62) | CTSKCTRB1CTSSCTSLPSMB5 | |
| SCHEMBL5724608 | 0.83 | CTSK (0.62) | CTSKCTRB1CTSSCTSLPSMB5 | |
| SCHEMBL5197783 | 0.83 | SYK (0.62) | SYKCTSKCTRB1CTSSCTSL | |
| SCHEMBL7496788 | 0.83 | SYK (0.62) | SYKCTSKCTRB1CTSSCTSL | |
| SCHEMBL2627375 | 0.82 | SYK (0.82) | SYKCTSKCTRB1CTSSCTSL | |
| SCHEMBL3582905 | 0.82 | SYK (0.82) | SYKCTSKCTRB1CTSSCTSL | |
| SCHEMBL3271846 | 0.82 | SYK (0.82) | SYKCTSKCTRB1CTSSCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6420427-B1 | PREVENTION AND/OR TREATMENT OF RHEUMATOID DISEASES, ARTHROSTEITIS, UNUSUAL BONE RESORPTION, OSTEOPOROSIS, PERIODONTITIS, INTERSTITIAL NEPHRITIS, ARTERIOSCLEROSIS, PULMONARY EMPHYSEMA, CIRRHOSIS, CORNEA INJURY | ONO PHARMACEUTICAL CO., LTD. (JP) | 2002-07-16 | — | — | US | disclosed |
| EP-1024134-A1 | AMINOBUTANOIC ACID DERIVATIVES | ONO PHARMACEUTICAL CO., LTD. (JP) | 2000-08-02 | — | — | EP | disclosed |