Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.42 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.42 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | LSS | P48449 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5454776 | 0.86 | CNR1 (0.44) | MAPK14MAPK11MAPK13MAPK12SMN1; SMN2 | |
| Water SCHEMBL27580375 | 0.73 | MAPK14 (0.70) | MAPK14MAPK11MAPK13MAPK12AKR1C3 | |
| SCHEMBL5258256 | 0.69 | MAPK11 (0.40) | MAPK14MAPK11MAPK13MAPK12LSS | |
| Hydrochloric Acid SCHEMBL27578484 | 0.69 | MAPK11 (0.40) | MAPK14MAPK11MAPK13MAPK12LSS | |
| SCHEMBL3322612 | 0.68 | SMO (0.51) | AKR1C3SMN1; SMN2ALDH1A1MAPTTRPV1 | |
| SCHEMBL14519689 | 0.68 | MAPK11 (0.70) | MAPK14MAPK11MAPK13MAPK12LSS | |
| Hydrochloric Acid SCHEMBL27575282 | 0.68 | MAPK11 (0.39) | MAPK14MAPK11MAPK13MAPK12LSS | |
| SCHEMBL5451516 | 0.68 | MAPK11 (0.75) | MAPK14MAPK11MAPK13MAPK12LSS | |
| SCHEMBL23410869 | 0.66 | MAPK14 (0.44) | MAPK14MAPK11LSSGRM5 | |
| SCHEMBL23410562 | 0.66 | PTGS2 (0.59) | MAPK14MAPK11MAPK13MAPK12LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423713-B1 | Substituted pyrazoles as p38 kinase inhibitors | G. D. SEARLE & COMPANY | 2002-07-23 | — | — | US | disclosed |