Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C1S | P09871 | 4/20 | 0.54 |
| ▸ | PLAU | P00749 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | HSD17B2 | P37059 | 5/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6925414 | 0.99 | C1S (0.53) | C1SPLAUHDAC3HDAC4HDAC1 | |
| SCHEMBL7735241 | 0.88 | C1S (0.53) | C1SPLAUHDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL6923914 | 0.87 | C1S (0.52) | C1SPLAUHDAC3HDAC4HDAC1 | |
| SCHEMBL6925814 | 0.84 | HPGD (0.54) | HDAC3HDAC4HDAC1HDAC6HPGD | |
| SCHEMBL7736159 | 0.78 | C1S (0.55) | C1SPLAUHDAC3HDAC4HDAC1 | |
| SCHEMBL7735938 | 0.76 | C1S (0.53) | C1SPLAUHDAC3HDAC4HDAC1 | |
| SCHEMBL7736645 | 0.76 | C1S (0.55) | C1SPLAU | |
| Hydrochloric Acid SCHEMBL6924633 | 0.75 | C1S (0.52) | C1SPLAUHDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL6925651 | 0.75 | C1S (0.54) | C1SPLAU | |
| SCHEMBL7359059 | 0.74 | C1S (0.53) | C1SPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6403633-B2 | USEFUL ANTIANGIOGENIC, ANTIARTHRITIC, ANTIINFLAMMATORY, ANTIRESTENOTIC, ANTIINVASIVE, ANTIMETASTIC, ANTIOSTEOPOROTIC, ANTIRETINOPATHIC, CONTRACEPTIVE AND TUMORISTATIC TREATMENT AGENTS | 3-DIMENSIONAL PHARMACEUTICALS, INC. | 2002-06-11 | — | — | US | claimed |
| WO-2000047194-A9 | METHODS OF TREATING C1s-MEDIATED DISEASES AND CONDITIONS, AND COMPOUNDS AND COMPOSITIONS THEREFOR | DIMENSIONAL PHARM INC (US) | 2001-05-31 | — | — | WO | disclosed |