Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 7/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 6/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.57 |
| ▸ | HTR2A | P28223 | 5/20 | 0.57 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.57 |
| ▸ | HTR2B | P41595 | 4/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.57 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.57 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.57 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.57 |
| ▸ | MTOR | P42345 | 2/20 | 0.57 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.57 |
| ▸ | DRD2 | P14416 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7734279 | 0.84 | LMNA (0.56) | GRIN2BADRA1AADRA2AHTR2AGRIN1 | |
| SCHEMBL7734180 | 0.83 | GRIN2B (0.80) | GRIN2BADRA1AADRA2AHTR2AGRIN1 | |
| SCHEMBL7735965 | 0.82 | DRD4 (0.56) | GRIN2BADRA1AADRA2AHTR2AGRIN1 | |
| SCHEMBL7733055 | 0.81 | GRIN2B (0.44) | GRIN2BADRA1AADRA2AHTR2AGRIN1 | |
| SCHEMBL7734147 | 0.79 | CCR3 (0.49) | GRIN2BADRA1AADRA2AHTR2AGRIN1 | |
| SCHEMBL10735593 | 0.74 | GRIN2B (0.85) | GRIN2BADRA1AADRA2AHTR2AGRIN1 | |
| SCHEMBL7723306 | 0.73 | LMNA (0.55) | GRIN2BADRA1AADRA2AHTR2AGRIN1 | |
| (R,S)-Ifenprodil SCHEMBL12618846 | 0.72 | GRIN2B (1.00) | GRIN2BADRA1AADRA2AHTR2AGRIN1 | |
| (R,S)-Ifenprodil SCHEMBL21614195 | 0.72 | GRIN2B (1.00) | GRIN2BADRA1AADRA2AHTR2AGRIN1 | |
| SCHEMBL10729816 | 0.72 | GRIN2B (0.81) | GRIN2BADRA1AADRA2AHTR2AGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6407122-B1 | NEUROPROTECTIVE AGENTS, ANTIISCHEMIC, AND HYPERGLYCEMIC AGENTS; HUNTINGTON*S, PARKINSON*S, AND ALZHEIMER*S DISEASE;AMYOTROPHIC LATERAL SCLEROSIS TREATMENT; NERVOUS SYSTEM AND BRAIN DISORDERS | PHARMACIA & UPJOHN S.P.A. (IT) | 2002-06-18 | — | — | US | disclosed |